4400 people, assumed to be dead or missing over the past fifty years, reappear in a ball of light. None have any memory of where they've been, and some are manifesting paranormal abilities.

Tom and Diana investigate a 4400 who has used his ability of enhanced reflexes to become a vigilante.

Tom and Diana investigate a 4400 junior high school teacher accused of child abuse.

A morbid premonition from Maia threatens the future of the 4400 Center.