Melinda is forced to remember how her relationship with her mother became strained after Melinda’s first ghost emerges. Melinda’s mother could not understand how to deal with Melinda’s gift. Melinda must reunite with her mother to help the ghost.

Melinda must help the ghost of an African-American man who had been attacked and killed by a white co-worker in the 1970's. The ghost is haunting the prosecutor who had enough evidence but still failed to file charges against the white co-worker. Melinda tries to help the ghost find justice and help his son to change his racist views before they're passed on to the next generation.

When Melinda meets a nightclub waiter who has not played his guitar since his friend died, she finds that he is being haunted by two ghosts.

Melinda has trouble talking to a ghost only to find that it's because he is not dead but is in a coma. While Lisa, his wife is in a legal battle against his parents to take him off of the life support. Meanwhile Delia struggles with teaching Ned about closure while also finding closure for herself.

Melinda becomes involved with a couple of ghosts who refuse to cross over after she finds that they are causing trouble for another couple. The ghosts make Melinda play a game of twenty questions.

Melinda reconnects with old high-school friends after one of their classmates dies mysteriously.

Melinda is pulled into a murder mystery by a real estate power couple when a ghost leads her to his own corps.