Two brothers, Sam and Dean Winchester, witness their mother's paranormal death as children and grow up trained to fight by a distraught father who wants nothing more then to hunt down the thing that killed his wife. Sam escapes to college to start a new, normal life, but gets pulled back in after Dean shows up on his doorstep to tell him their father is missing.

Following clues from an eerie phone message from him, the boys travel to a small town and encounter a vengeful spirit called the "Woman in White" who then starts to haunt Sam.

Sam is haunted by a vision of a woman trapped in his childhood house and convinces a reluctant Dean that they need to go home. Upon arrival, they meet the woman in Sam's premonition and she reveals that the house is haunted. Looking into their personal history, the brothers discover their father had visited a psychic after their mother's death and they turn to the same woman for answers of their own. Together they discover a malevolent poltergeist has inhabited the house and set out to exorcise it, but are blindsided when another unseen spirit steps in.

Sam has a reunion with a girl he once met, Meg, but it turns out that she is using the brothers to lure their father John to his doom.

When Meg boasts that John is her prisoner, the boys visit a friend of their father's to get information about demonic possessions and ways to trap a demon. It turns out Meg is not what she appears.

In the aftermath of the car crash, the surviving Winchesters go to the hospital, where one is stalked by a Reaper while another must consider sacrificing himself to save the others.

Dean is attacked by a Djinn... and finds himself in a new reality where his mother is still alive and a mysterious woman holds the key to everything.

Seven demons, based on the Seven Deadly Sins, are released into the world and the brothers must combat them with the aid of a married Hunter couple.

Sam, Dean, and Bobby hunt down Lilith and fight her and her demons in a final effort to save Dean's life.

Dean wakes up in his own coffin. How did he return from the dead? What caused the hand-shaped welt on his shoulder? And what happened in the four months he spent in Hell, time he can't remember?

The brothers prepare to fight the forces of the apocalypse in different camps. While Sam and Ruby hunt down Lilith, Dean joins Castiel and Zachariah to take on Lucifer.

Sam, Dean, and Bobby must deal with the aftermath of the Devil's escape from Hell, and receive startling news from the Prophet Chuck.

Sam investigates a case about missing babies whose parents are being murdered. At one of the crime scenes, he discovers a baby that was left behind and calls Dean for help. Reluctant to leave Lisa and Ben, Dean finally agrees to meet Sam and surprises his brother with how parental he has become. The brothers take the baby to Samuel, who decides to raise it as a hunter, which infuriates Dean. However, before they can decide the baby's future, a shape-shifter breaks in and attempts to kidnap the baby.

The wall comes down in Sam’s head and all hell breaks loose. Dean and Bobby are, for once, at a total loss on how to help him and are forced to stand by and do nothing while Sam breaks. The battle for heaven comes to a head.

With the plan in full motion, Sam, Dean, Castiel and Jack fight for the good of the common goal.