Sam is mysteriously released from Hell and seeks out his brother, trying to have a normal life. Together the brothers must join forces with their maternal grandfather, Samuel, and begin the fight anew.

Sam investigates a case about missing babies whose parents are being murdered. At one of the crime scenes, he discovers a baby that was left behind and calls Dean for help. Reluctant to leave Lisa and Ben, Dean finally agrees to meet Sam and surprises his brother with how parental he has become. The brothers take the baby to Samuel, who decides to raise it as a hunter, which infuriates Dean. However, before they can decide the baby's future, a shape-shifter breaks in and attempts to kidnap the baby.

Sam and Dean call Castiel for help when they investigate a case about several dead police officers who seem to have been killed by the plagues of Egypt. Castiel confirms the staff of Moses was used to kill the cops and tells Sam and Dean that Heaven is in a state of chaos and God's weapons have been stolen. The three head off to find the thief and come face to face with an old enemy.

After Bobby discovers Crowley has no intentions of returning Bobby's soul, the hunter takes matters into his own hands. He calls on Sam and Dean for help after he unearths one of Crowley's deepest secrets. Meanwhile, Sam and Dean learn what Bobby does all day when they are not around.

After a group of young girls go missing Sam and Dean realize that a group of vampires have taken up residence in the small town. After a fight with two of the blood-suckers, Dean is bitten and turns into a vampire. Samuel tells Dean he can change him back but he’d have to get the blood of the vampire who turned him. Dean infiltrates the nest and runs into the Alpha...

Sam and Dean investigate a series of suicides and discover the victims were being told brutal truths that drove them crazy. They find out someone is invoking the Goddess of Truth, Veritas, forcing people to be cruelly honest against their will and Dean is the next victim. Dean is forced to tell Sam the truth about how he feels about his return from Hell.

Dean becomes suspicious of Samuel's motives, but Sam isn't sold on the idea that their grandfather is doing anything wrong. The brothers go along on a hunt with Samuel and the other Campbells, but things go terribly awry.

Dean and Sam investigate what seems to be a werewolf killing but turns out to be a skinwalker posing as a family dog who is taking revenge on his owner’s enemies.

While Sam and Dean are investigating a UFO sighting, Dean is abducted from a crop circle. However, when he awakens, he discovers he isn't dealing with aliens, but fairies! Unfortunately, only Dean can see the fairy that keeps attacking him which makes tracing and stopping them difficult. The brothers become even more perplexed when Sam's investigation leads them to a world full of elves, gnomes and a leprechaun.

Meg kidnaps Sam and Dean and tries to force them to tell her where Crowley is hiding. Sam makes her a deal - they will help her find Crowley if she promises to torture him for information about how to get Sam's soul back. Castiel joins the fight but finds it difficult to work with Meg.

Dean seeks out Death to help get Sam's soul back. Death tells Dean he will help Sam if Dean will agree to act as Death for 24 hours. Meanwhile, Sam decides he doesn't want his soul back and asks Balthazar for a protective spell to keep his soul out of his body. Balthazar tells Sam he needs the blood of his father for the spell to work and since John Winchester is dead, Sam decides Bobby is the next best thing.

Dean and Bobby anxiously wait for Sam to wake up to see if Death was able to restore his soul without causing Sam to lose his mind. Meanwhile, Dean and Bobby investigate a disappearance of virgins and discover dragons are behind the kidnappings. Bobby sends Dean to a doctor who owns the only weapon in the world that can slay a dragon, but Dean must prove himself worthy enough to take it

Sam starts to have flashbacks to a case he worked on with Samuel before he reconnected with Dean. Sam receives a mysterious text with coordinates to a small town, so the brothers decide to investigate. Dean is surprised when the townspeople start telling him some of the things Sam did while he lived there.

Ben calls Dean and tells him Lisa is in trouble. Dean leaves Sam to investigate a case alone and rushes home to rescue Lisa, however, he’s not prepared for what meets him at the door. Meanwhile, Sam discovers the men that were murdered were all a part of a cruel practical joke played on a female co-worker who went missing.

Dean and Sam find themselves in an alternate reality where everyone believes they are two actors named Jensen Ackles and Jared Padalecki, who star in a TV show called Supernatural about two brothers who hunt monsters.

Eve, the Mother of All, unleashes a new monster upon the world: a black worm-slug that can enter the brain and force people to kill. Sam and Dean join forces with Bobby and Rufus and track it to a cannery, only to discover that Gwen and Samuel are also there looking for the monster... and none of them know who the monster is inside.

After Balthazar changes history and keeps the Titanic from sinking, Fate intervenes and begins killing those that would have died on the ship. Castiel tells Sam and Dean that Fate is very upset with the two of them and the only way they can stay alive is to kill her.

While searching for a way to defeat Eve, Dean stumbles upon Samuel Colt’s journal in the Campbell library. Realizing Samuel might have the answer to their problems, Sam and Dean ask Castiel to send them back in time so they can meet the man himself. While Sam is a bit reluctant to time travel, Dean is beside himself with excitement to return to the Wild, Wild West.

Sam, Dean, Bobby and Castiel track Eve to a small town in Oregon. The guys discover the townspeople have been converted to demons, but surprisingly, they all appear to be dying. When they finally do meet Eve, she decides to torture the brothers by bringing back their mother.

Castiel tells Sam, Dean and Bobby about the war in Heaven and how he and Raphael became enemies. Bobby believes Castiel is hiding something, but Dean refuses to believe it.

A demon kidnaps Ben and Lisa to get to Dean. Sam and Dean are forced to join with an unlikely ally to free them.

The wall comes down in Sam’s head and all hell breaks loose. Dean and Bobby are, for once, at a total loss on how to help him and are forced to stand by and do nothing while Sam breaks. The battle for heaven comes to a head.

While Sam hangs on the edge of life and death, Dean appeals to the fallen angels for help. Unfortunately, most of them only see Dean as a means to get to Castiel and exact bloody vengeance on the one who caused them to Fall. Meanwhile, Sam wrestles with his inner demons and Castiel learns what it means to be human.

Dean and Sam take a captive Crowley to the Men of Letters base in the hopes that he will give up the names and host bodies of his minion demons. However, they are called away to investigate the disappearance of three soldiers, which leads them to Abaddon, the Knight of Hell... and forces Ezekiel to take control of Sam's body to save his life.

Castiel makes his way to the Winchesters but discovers a band of angels are hunting him, intent on making him pay for what they believe is his role in banishing them from Heaven. Meanwhile, Ezekiel continues to repair Sam's price, but informs Dean that there is a cost to be paid.

With some help from Charlie, Sam and Dean inadvertently release two individuals contained inside of the Men of Letters bunker: an evil witch, and a young woman, both imprisoned since 1935. They soon discover that the woman is Dorothy of Oz, and she is hot on the trail of the Wicked Witch, who plans to summon her evil army to Earth and conquer the planet.

To track down a killer, Dean uses a spell to talk to a German Sheppard that was at both murders. However, he soon discovers that everything is going to the dogs when the spell starts making him act like a canine as well.

Castiel is working as a convenience store clerk and learns of a series of local disappearances. He call the Winchesters, but Dean insists on Sam staying with Kevin to research the Tablet while he investigates.

Sonny, a man who runs a boy's home, calls Dean in after a mysterious death occurs. When Sam wonders how his brother knows Sonny, Dean explains that he spent two months there when he was 16 after being arrested for theft.

When a mysterious abductor targets members of a virgin chastity group, Sam and Dean go undercover to track down the killer when Sheriff Jody Mills asks them for help. However, Dean disappears and Sam and Jody end up tracking him down.

The angels fight each other in bloody civil war, and Castiel is swept up in the conflict. Meanwhile, Dean realizes that Ezekiel is not who he claims to be and tries to warn Sam with dire results.

Dean and Castiel make a deal with Crowley to contact Sam's consciousness so he can expel the angel Gadreel from his body. However, Abaddon is hot on their trail and Crowley has plans of his own.

Crowley turns to Dean for help to locate the First Blade, the only weapon that can kill Abaddon. However, they soon discover that the trail leads to Cain... the Father of Murder and the most powerful demon of all time. Meanwhile, Sam asks Castiel for help when they need to extract the remaining grace from Sam's body to track Gadreel.

Six months after his disappearance, Garth turns up injured in a hospital. Sam and Dean arrive separately to investigate and soon discover that their friend has undergone a startling transformation... and found others who share his condition.

Two victims die and the fat is stolen from their bodies. Dean and Sam investigate a local spa and go undercover, and discover that a monster is preying on the overweight.

While Sam and Dean try to track down Kevin's mother, Castiel is captured by an old battle-comrade and learns more about the factions of angels.

The brothers investigate a mysterious murder that was apparently caused by a ghost, and discovers that the Ghostfacers, Ed and Harry, are already on the case. However, the facts don't add up and the Winchesters realize that something more is going on.

Sam and Dean track down the missing Crowley and discover that he's now thoroughly addicted to human blood. Once they get him sober, the brothers go seeking the First Blade and find it in the possession of a former Man of Letters... who plans to add Dean to his collection.

When Dean chooses to stay in the bunker and try and locate Abaddon, Sam goes to a small Illinois town to investigate a string of vicious murders committed by seemingly harmless individuals. He's unaware that Dean has actually gone out drinking to deal with the strain of unleashing the Mark of Cain.

Castriel investigates the mass slaughter of angels and finds a lone survivor... and an old friend. Meanwhile, Sam and Dean capture Gadreel, and Metatron begins the ending of his story.

Sheriff Jody befriends a young girl on the run from vampires. When she's forced to kill one of the monsters, Jody calls in Sam and Dean for help. However, they discover that everything isn't at it seems when the girl wants to go back to the vampires.

Sam and Dean learn about a monster killing in Chicago and head there to investigate. What they find is a young cop whose girlfriend was killed by the same creature, and who is caught between five powerful clans of monsters who jointly control the city. However, war is about to break out and the sides are drawn as the Winchesters discover that the original victim belonged to one of the clans.

Abaddon finally gets something that she can use as leverage against Crowley to force him to lure the Winchesters. Meanwhile, Castiel rallies his forces and asks Sam and Dean to come in and help him interrogate a captive angel with ties to Metatron.

After a suicide angel takes out an ice cream shop to kill one enemy angel, Sam and Dean investigate and discover that the target was one of Metatron's angels... and that Castiel may be responsible. Meanwhile, Metatron tries to consolidate his hold over the angel factions with promises that he will restore them to Heaven.

After attacking Gadreel, Dean leaves with Crowley to track down Metatron and kill him. Meanwhile, Gadreel takes Castiel into Heaven to try and break Metatron's connection to the angel tablet, stripping him of his powers.

Dean is a demon and running amuck with Crowley while Sam tries to figure out what happened to his brother. Meanwhile, Castiel is dealing with his diminishing grace.

Crowley is worried about Dean getting out of control, giving him a target to feed the mark. Sam struggles to escape from Cole. Hannah tries to convince Metatron to give Castiel's grace back.

Sam continues to try to save Dean from the Mark of Cain. Realizing that Dean's antics are causing problems for him in hell, Crowley seeks help from a reluctant Castiel.

Sam and Dean investigate a series of werewolf attacks in an attempt to find out who the culprit is.

Sam and Dean investigate a haunting at a theatre.

Dean encounters a surprising message on Bobby's phone, and Sam and Dean investigate.

Sam and Dean discover a group of witches "gone wild" and they attempt to stop them.

Jody Mills is matched with an overeager partner during a mandatory sheriff's retreat; when a gruesome corpse is discovered, Jody calls Sam and Dean to help investigate.

Castiel finds Jimmy’s daughter Claire in a group home and she convinces him to break her out. After she runs away from him, Castiel calls Sam and Dean to help find her before she gets in trouble. Meanwhile, Crowley faces his biggest challenge yet.

After the massacre at the ranch, Dean, Sam, and Castiel double their efforts to find a cure for the Mark of Cain but there is nothing in the lore that can help them. Desperate, Castiel comes up with an idea that Sam deems the "single worst idea I've ever heard." Meanwhile, Rowena continues to plot against Crowley, and Castiel tries to mend his relationship with Claire who is plotting revenge against Dean for killing her friend.

Sam is scanning the internet for suspicious paranormal activity and comes across a video of Charlie beating up a district attorney. Dean suspects she’s back from Oz and hunting on her own, assuming the district attorney must have been a demon. When they do find Charlie, they are shocked when she tells them why she really came back from Oz.

Looking to get Dean out of the bunker, Sam finds a case for him and Dean to investigate – people are disappearing into thin air with only their clothes left behind.

A ghost starts killing people through various electronic devices. Sam and Dean discover who was killed and why this ghost is seeking revenge on a group of college students but what they can't figure out is how he’s doing it. With three dead, the brothers must stop the ghost before he claims his next victim.

Dean, Sam and Castiel deal with Cain’s return. Crowley and Rowena continue to grow closer but when Crowley bails on plans with his mother to help the Winchesters, Rowena lets him have it.

Despite Dean's directive to forget about looking for a cure for the Mark of Cain, Sam continues to do research. Dean suspects Sam is hiding something but decides to focus on a new murder case where they run into Cole. The three team up and learn a Khan worm is infecting men and turning them into murderers. Unfortunately, the worm makes its way into Cole.

Sam and Dean investigate a string of suicides committed by people with little in common other than the identical, grisly method of death – slow, self-administered disembowlment. All of the victims were members of a Catholic church and had recently given confession, leading the brothers to suspect the priest is somehow involved. Meanwhile, when Crowley captures Olivette, the leader of the Grand Coven, Rowena pleads her case to be allowed to practice magic freely again.

Sam and Castiel follow up on a lead about the Mark of Cain. Dean and Rowena meet.

Charlie calls Sam and Dean to tell them she found the Book of the Dead which could help remove the Mark of Cain. The Winchesters race to her after she tells them she’s been shot by a man named Jacob Styne who says the book belongs to his family and he won’t rest until he gets it back. Castiel and Metatron take a road trip to find Castiel’s grace but they hit a couple road bumps along the way.

Sam learns that former Men of Letters, Magnus, once built a magical box and Sam sets out to find it in the hopes it can cure Dean of the Mark of Cain. However, what he’s not prepared for is the deadly alarm system Magnus set up on the box. When Sam opens the box, he puts both his and Dean’s life in danger.

When Claire Novak gets a lead on her mother, Amelia, who has been missing for years, Castiel asks Sam and Dean to help her. Castiel feels guilty for what he did to the Novak family and wants to make amends by reuniting Claire with her mom. However, when they find out what took Amelia, they realize there is a chance Claire may not get her happy ending.

Dean and Sam investigate a bizarre murder and realize the killer bears the same tattoo as those from the Styne family. Eldon Styne attacks Dean and a brutal fight ensues. Meanwhile, Castiel acts as referee when Charlie and Rowena are forced to work together on the Book of the Damned. Crowley discovers his mother is missing and knows she's up to something so he turns to an old enemy for help.

When it comes to the Stynes, Dean decides to take matters into his own hands. Sam tries to come to terms with his decision.

Dean makes a shocking decision regarding the Mark of Cain that would change not only his life, but Sam’s too. Meanwhile, Crowley and Rowena face off and Castiel gets caught in the middle.

Picking up where the finale left off, Sam and Dean must deal with the Darkness that has been unleashed. Castiel deals with the effects of Rowena’s spell and recalls his brutal battle with Crowley.

Dean helps Jenna, the deputy he met after the Darkness fell, get back home safely and then sets off to help Sam deal with a town infected by a mysterious and deadly gas. However, when Jenna falls into dangerous hands, she calls Dean for help and Sam tells him to go back to her. Unfortunately for Sam, he isn't able to handle the townspeople turned monsters as easily as he thought.

While Rowena tries to consolidate her power to protect herself from the Winchesters, Sam and Dean search for a missing baby connected to the Darkness. Meanwhile, Castiel struggles to heal and Crowley tries to find a way to use the Darkness for his own personal gain.

Seen entirely from the point of view of the Impala, Sam and Dean go on a road trip to fight monsters and demons.

Sam and Dean investigate a series of murders at a local B&B that also happens to be Lizzie Borden’s old home. When a local man, Len, tells them he saw a little girl around the B&B around the time of the murders, the brothers realize Amara may be responsible.

Castiel seeks out Metatron’s help to stop the Darkness. However, Metatron is pretty happy with his new life as a freelance videographer for the local news and isn’t inclined to help the Winchesters or Castiel. Meanwhile, Crowley is losing his hold on Amara.

Sheriff Donna calls Sam and Dean for help after a horrific murder with supernatural elements happens in her town. Sam continues to have visions and asks God for help, which frustrates Dean.

Sam is shocked when his childhood imaginary friend Sully makes an unexpected appearance. Sam can’t understand why he’d see Sully now but what’s even more surprising is that Dean can see him, too. Flashbacks reveal young Sam’s friendship with Sully and why he needed him.

Amara unleashes her power on the local townspeople as she issues a shocking challenge. Dean tries to better understand the hold Amara has on him, while Sam and Crowley come up with a plan that could have disastrous consequences.

Now that he has Sam in the cage with him, Lucifer offers Sam a way out but it comes with a steep price. Dean and Castiel look into the angel smiting that could have killed Amara.

Sam and Dean investigate a case where people are suffering violent deaths after hearing a mysterious song.

Sam and Dean drop in on Jody Mills, Claire and Alex after receiving a panicked phone call from Claire. She believes the recent murders in town are supernatural and wants the boys’ help. However, Sheriff Mills tells Sam and Dean that Claire has been getting into trouble lately as she’s been attacking normal people and accusing them of being monsters.

Sam and Dean investigate a set of murders on Valentine’s Day and discover they are dealing with an ancient curse. Once kissed by the curse, the person is marked to die.

Hoping to find a weapon powerful enough to defeat Amara, Dean convinces “Castiel,” who is still Lucifer, to send him back in time to 1944 to the fated submarine mission that sunk the Hand of God. Meanwhile, continuing his charade with Sam while they wait for Dean’s return, Lucifer plans his next move.

Sam and Dean attend a wrestling match to relive one of their fondest memories but when a wrestler turns up dead they suspect foul play.

A dangerous creature is accidentally released into an old house, attacking a mother and her child, leaving them both in a coma. Sam and Dean learn that Bobby and Rufus once tracked the same entity so the Winchesters look to the past to come up with a plan to catch the monster before any one dies.

Sam and Dean battle a pair of werewolves who have captured two victims. Just as the brothers are about to win, one of the werewolves shoots Sam. Dean gets his brother and the victims out of the house but learns a pack of werewolves are hot on their tail, hoping to kill them all.

Lucifer takes a trip home and tries to assert himself into Heaven. Crowley tells Sam and Dean he has a way to take down Amara.

In a small town in Colorado, mysterious disappearances happen every 27 years. Sam and Dean head to the town to investigate and meet two hunters who have a personal vendetta against these once-in-a-generation monsters.

Amara unleashes a dark fog on a small town, causing everyone to go mad. Dean and Sam realize this is a stronger version of the original black vein virus Amara previously unleashed. They team up with the sheriff to protect the town but their old remedy no longer works. Meanwhile, Chuck returns with an interesting proposal.

Amara shows Dean how she’s torturing Lucifer. Worried for Castiel, Dean and Sam come up with a plan to rescue him from Amara’s clutches.

Sam and Dean face their biggest challenge yet. Rowena makes her move.

God comes to a decision about Amara that has direct repercussions for Sam and Dean.