In a small town in Colorado, mysterious disappearances happen every 27 years. Sam and Dean head to the town to investigate and meet two hunters who have a personal vendetta against these once-in-a-generation monsters.

Lucifer realizes that as rock star Vince Vincente, he can get his fans to do whatever he wants. Thrilled with this power, Lucifer arranges to play a secret VIP concert in order to kill all of them. Sam, Dean and Castiel enter the underbelly of the music industry to try to stop him.

Sam, Dean and Castiel search for Lucifer who, meanwhile, strikes an unlikely deal with a local faith healer named Sister Jo. Asmodeus inches closer to finding Jack.

When Sam and Dean join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel to make an enormous sacrifice to make things right.

Sam and Dean discover a wood nymph living in the bunker who is determined to protect her family, at any cost.