Sam and Dean investigate a case that leads them to a devout religious family that lives off the grid. The brothers realize that the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary’s latest decision.

Mary asks Sam, Dean and Castiel for help on a case she’s working but neglects to mention the British Men of Letters are involved. When Mary is double crossed, everything is revealed.

An attack by an invisible hellhound at a campsite leads Sam and Dean to investigate the mysterious circumstances. Meanwhile, two of Crowley’s own personal demons uncover what he has been hiding. Castiel gets a lead on Kelly Kline.

Castiel is reunited with Jack and together with Sam and Dean, they head to a sleepy old western town to investigate a murder. Dean gets to live out his boyhood fantasy when he comes face to face with a famous, gun-slinging outlaw.

Donna calls Sam and Dean for help after her niece, Wendy, goes missing. The three hunters discover Wendy was kidnapped by a man who sells human parts to monsters in a grotesque online auction and race to save her before it is too late.

Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.

Dean continues to struggle. Meanwhile, Sam must think fast when action figures come to life, and our heroes find themselves living in a real-life horror movie.

Dean spends some bonding time with Mary and Donna. Nick finally finds the answer he has been searching for. Sam is left to make an unimaginable choice.

Sam and Dean investigate the mysterious death of a girl and the disappearance of another.