Sam and Dean let Mick Davies tag along on a case as they search for a werewolf. The three men run into Claire Novak, also working the hunt. However, the reunion is short lived after Claire is bitten and the brothers race to find a way to help her before she turns.

Donna calls Sam and Dean for help after her niece, Wendy, goes missing. The three hunters discover Wendy was kidnapped by a man who sells human parts to monsters in a grotesque online auction and race to save her before it is too late.

Lucifer rules over heaven but things aren’t going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.

Dean continues to struggle. Meanwhile, Sam must think fast when action figures come to life, and our heroes find themselves living in a real-life horror movie.

Sam and Dean enlist the help of their pal Garth to gain inside information on what Michael may be planning. The brothers split up to each go after weapons that can aid in their fight against the Archangel, but this may be a fight our heroes cannot win.

Dean tager afsted på egen hånd for at undersøge en sag. I mellemtiden har Castiel en idé til, hvordan han kan hjælpe Sam med at opspore Gud.

I jagten på det, der måske kan give Sam og Dean en fordel mod Gud, ender de ved Jos dør og ved en hemmelighed, der kan være i begravet med Ruby. Derudover beder Castiel Jack om at gøre det utænkelige.

Sam og Dean bliver bedt om at undersøge mordet på en barndomsven, hvilket minder dem om et motel fra deres fortid og forvirrer brødrene med en sag, de troede blev løst for længe siden.