God comes to a decision about Amara that has direct repercussions for Sam and Dean.

Dean is overwhelmed as he comes face to face with his mom, Mary Winchester. Meanwhile, Sam is fighting for his life after Toni, from the Woman of Letters, shot him.

Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable with putting Mary in danger but she insists on going along. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.

Alicia Banes calls Mary for help after her mother, Tasha, goes missing. Sam answers Mary’s phone and he and Dean head out to help Alicia and her twin brother, Max, find their mother who was hunting a powerful witch. Meanwhile, Mary starts to have some doubts about the British Men of Letters.

Sam and Dean are alarmed when they learn hunters are being killed by suspicious “accidents” all over the country. They decide it is best to find Mary and make sure she’s safe. Meanwhile, Toni is back in the states and she and Mary face off.

Caught in a dangerous situation, Sam and Dean only have each other to rely on. Meanwhile, the fight between the American Hunters and the British Hunters comes to a head.