Sam and Dean reunite with Castiel. Digging through the Men of Letters' files, they stumble upon an undiscovered film which could be the key to the third trial. Metatron enlists Cass to mull over problems at home. Meanwhile, Crowley digs into Sam and Dean's past.

Abaddon finally gets something that she can use as leverage against Crowley to force him to lure the Winchesters. Meanwhile, Castiel rallies his forces and asks Sam and Dean to come in and help him interrogate a captive angel with ties to Metatron.

Sam continues to try to save Dean from the Mark of Cain. Realizing that Dean's antics are causing problems for him in hell, Crowley seeks help from a reluctant Castiel.

Sam and Dean discover a group of witches "gone wild" and they attempt to stop them.

Castiel finds Jimmy’s daughter Claire in a group home and she convinces him to break her out. After she runs away from him, Castiel calls Sam and Dean to help find her before she gets in trouble. Meanwhile, Crowley faces his biggest challenge yet.

After the massacre at the ranch, Dean, Sam, and Castiel double their efforts to find a cure for the Mark of Cain but there is nothing in the lore that can help them. Desperate, Castiel comes up with an idea that Sam deems the "single worst idea I've ever heard." Meanwhile, Rowena continues to plot against Crowley, and Castiel tries to mend his relationship with Claire who is plotting revenge against Dean for killing her friend.

Dean, Sam and Castiel deal with Cain’s return. Crowley and Rowena continue to grow closer but when Crowley bails on plans with his mother to help the Winchesters, Rowena lets him have it.

Sam and Dean investigate a string of suicides committed by people with little in common other than the identical, grisly method of death – slow, self-administered disembowlment. All of the victims were members of a Catholic church and had recently given confession, leading the brothers to suspect the priest is somehow involved. Meanwhile, when Crowley captures Olivette, the leader of the Grand Coven, Rowena pleads her case to be allowed to practice magic freely again.

Sam and Castiel follow up on a lead about the Mark of Cain. Dean and Rowena meet.

Charlie calls Sam and Dean to tell them she found the Book of the Dead which could help remove the Mark of Cain. The Winchesters race to her after she tells them she’s been shot by a man named Jacob Styne who says the book belongs to his family and he won’t rest until he gets it back. Castiel and Metatron take a road trip to find Castiel’s grace but they hit a couple road bumps along the way.

Sam learns that former Men of Letters, Magnus, once built a magical box and Sam sets out to find it in the hopes it can cure Dean of the Mark of Cain. However, what he’s not prepared for is the deadly alarm system Magnus set up on the box. When Sam opens the box, he puts both his and Dean’s life in danger.

Dean and Sam investigate a bizarre murder and realize the killer bears the same tattoo as those from the Styne family. Eldon Styne attacks Dean and a brutal fight ensues. Meanwhile, Castiel acts as referee when Charlie and Rowena are forced to work together on the Book of the Damned. Crowley discovers his mother is missing and knows she's up to something so he turns to an old enemy for help.

When it comes to the Stynes, Dean decides to take matters into his own hands. Sam tries to come to terms with his decision.

Dean makes a shocking decision regarding the Mark of Cain that would change not only his life, but Sam’s too. Meanwhile, Crowley and Rowena face off and Castiel gets caught in the middle.

While Rowena tries to consolidate her power to protect herself from the Winchesters, Sam and Dean search for a missing baby connected to the Darkness. Meanwhile, Castiel struggles to heal and Crowley tries to find a way to use the Darkness for his own personal gain.

Amara unleashes her power on the local townspeople as she issues a shocking challenge. Dean tries to better understand the hold Amara has on him, while Sam and Crowley come up with a plan that could have disastrous consequences.

Now that he has Sam in the cage with him, Lucifer offers Sam a way out but it comes with a steep price. Dean and Castiel look into the angel smiting that could have killed Amara.

Lucifer takes a trip home and tries to assert himself into Heaven. Crowley tells Sam and Dean he has a way to take down Amara.

Sam and Dean face their biggest challenge yet. Rowena makes her move.

God comes to a decision about Amara that has direct repercussions for Sam and Dean.

Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable with putting Mary in danger but she insists on going along. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.

When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel’s hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.

Lucifer’s search for power and influence in a vessel lands him in the White House. The President of The United States unknowingly makes a deal with the devil, leading Sam, Dean, Castiel, Crowley and Rowena to band together to fight the Dark Lord.

Sam enlists Rowena’s help to track down an old world, powerful family of witches after Dean gets hit by a spell that is rapidly erasing his memory.

When Sam and Dean look into a murder at a museum, they learn a ghost from a merchant ship that sunk in 1723 may be at the heart of the mystery. After realizing “The Star” was the same ship that Crowley’s son Gavin McLeod should have been aboard, they enlist help from Rowena to track Gavin down. Kelly Kline, still pregnant with Lucifer’s child, takes refuge with a demon after an angel attempts to kill her.

Lucifer battles Sam, Dean and Castiel for control of his unborn child.

As Sam and Dean continue their search for Jack, with Asmodeus hot on their trail, they stumble across a familiar foe. Meanwhile, Lucifer manages to escape Michael’s grasp and finds himself an unlikely and mostly unwilling ally.

Dean falls victim to a couple of witches, sisters Jamie and Jennie Plum, who manage to steal a powerful book of spells from the Winchester brothers. When Sam and Dean go after the book, they get help from a powerful and surprising ally when Rowena, back from the dead, intervenes to assist them.

Sam and Dean must stop Rowena, who is on a deadly mission. Meanwhile, Castiel looks to heaven to recruit angels for an impending invasion but is shocked by not only what he finds, but who.

Gabriel is back and drags Sam and Dean into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's inflating confidence leads to reckless decisions that could put others in harm's way.

Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena’s encounter with Lucifer may alter the outcome of the journey for one of our heroes.

Sam and Dean devise a plan that will save innocent lives. Meanwhile, Jack continues to wrestle with the consequences of his decisions.

Our heroes, Sam and Dean Winchester, continue to be tested in the battle between good and evil, but one impulsive decision could alter the lives of one the brothers forever.

Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to be a father figure to Jack, who surprises even himself, when a life is on the line.

Sam and Castiel track down a Shaman, who may be able to help a friend. Nick continues to spiral down a dark path as he looks for answers surrounding the deaths of his wife and son. Jack turns to Dean for help enjoying the human experience.

Sam and Dean enlist the help of Rowena to track down a demi god who feasts on human flesh. The challenge of keeping Michael at bay is proving to be more difficult than originally anticipated.

Sam and Dean continue to worry about the condition of Jack’s soul.

Sam, Dean and Castiel call on Rowena to help keep the evil souls at bay and get an unexpected assist from Ketch.

Sam and Dean together with Rowena work tirelessly to keep all of hell from breaking loose. Castiel cannot forgive an arrogant betrayal.

Sam and Dean are visited by an old friend. Castiel investigates the disappearance of a local teen.

Sam, Dean and Castiel’s continued search for a way to defeat Chuck leads them to unexpected places and toward unlikely allies.

A search for the one thing that may give the Winchesters an edge against God leads Sam and Dean to Jo’s door and to a secret that may have died with Ruby. Meanwhile, Castiel asks Jack to do the unthinkable to help the brothers in their quest.

Castiel and Jack work a case involving members of a local church. Meanwhile, Sam and Dean go off in search of Amara.