Things don't look good for the Sliders when they slide to a world that's about to be eradicated by a rogue pulsar. Soon they discover that this world has been developing sliding technology and pool their resources with the U.S. government in a race to escape to a parallel Earth.

Quinn and Maggie return to her world with Earth Prime's coordinates stored in Jensen's timer. As Wade makes the final list for those who can slide to safety, Arturo races to modify the new timer to slide more people. Unfortunately for them, an unexpected danger lurks the base and one Slider will not make it to the next world.

The Sliders arrive on a world where a strange bacteria transformed the inhabitants into flesh-eating zombies. When Quinn is bitten, he begins to turn into one of them.

A creature embeds a parasite in Maggie just before the slide, which takes the Sliders to a world where young adults are used in a mandatory organ-donor program. The others will have to find Maggie before she finds the perfect mate and lays her eggs.

The Sliders track Rickman to a superstitious town. Their search is further complicated when Quinn and Maggie are captured by natives living in a mysterious fog. There, Quinn runs into someone from his past--himself.

While on vacation, Quinn and Rembrandt get mixed up in an illegal snake deal and find themselves stuck in the middle of no where surrounded by deadly snakes. Meanwhile, Wade and Maggie get involved with a shady man in their search for the others.

The Sliders' chase for Rickman takes them back to the world they helped colonize, the New World. Only they find that the colonists are being hunted by a hungry Tyrannosaurus Rex.

Wade falls under the spell of a rock band's charismatic lead singer, who is really a vampire and looking to use Wade to get the timer. Meanwhile, the others try to track down Rickman.