Sketches include "Bush Responds to Criticism," "Nelson's Baby Toupees," "Jamba Juice," "Larry King Live," "The Couple That Should Be Divorced," "Belated Black History Moment" (cartoon), "Art Dealers and the College Boyfriend," "Sheldon's Bar Mitzvah," "The Real Natalie" (film), and "RAD 3000."

Fall Out Boy performed "Dance Dance" and "Sugar, We're Going Down."

Academy Award winner Natalie Portman returns for the second time as host and pop artist Dua Lipa joins as musical guest for the first time.