Velma and Hot Dog Water (Marcie) go to Russia on a mission for Mr E, and bring back an old house which springs legs and runs rampage over town. Meanwhile the gang are looking to replace Daphne and Velma suggests Hot Dog Water.

Fred tries to get Daphne back. Crybaby Clown returns to rob Crystal Cove and kidnaps Daphne as well. Daphne is rescued and agrees to return to the gang. Mr. E tries to re-recruit Angel Dynamite.

Dreamweaver has come to life brainwashing an old group of Crypts and Creepers players (including Sheriff Bronson Stone) by entering their minds while they sleep!

Gary and Ethan are attacked by the Dark Lilith on Mount Diabla and lose the soccer team's lucky soccer ball.

As the gang follows the original Mystery, Inc. through the caverns, they all approach the first gate to the cursed treasure. Professor Pericles knows the gang has been following them, as he calls them out to bring the Keys in order to open the gates. The gang realizes that the Keys and their scenarios seen in the dream world is how they all apply to the gates and the gates being opened. The gang decides to cooperate, after Pericles reveals that they have Hot Dog Water, and opens the first gate. Thanks to Hot Dog Water, the gang enters the first gate; however, Hot Dog Water is killed by the Kriegstaffelbots nearly straight afterwards. The gang arrives at the second gate, and opens it using the mortar bowl. They enter a mysterious rock dimension, where they are greeted and chased by a Rock Monster. After the monster's failure, the gang comes before the third gate, which is opened using the conquistador's helmet. The gate then releases water trapped behind and turns into a boat, allowing Scooby and the gang to escape and become stranded at sea. After learning that the next gate is below the water, the gang comes upon the final gate, which is opened using the flintlock. The gang enters the dimension, which is teeming with lava, and come upon the crystal sarcophagus and cursed treasure, realizing that they are beneath Crystal Cove. The Evil Entity sealed within tries to manipulate the gang into opening the sarcophagus to free it, but the gang realizes the words the being is speaking aren't true. Suddenly, Pericles and the original Mystery Incorporated arrive and Pericles opens the sarcophagus, releasing the Evil Entity.

The gang and original Mystery Incorporated stand before the Evil Entity. The Entity grabs Scooby-Doo, and mentions that he must die and be reborn as a vessel to its darkness. Scooby breaks free, but Pericles volunteers to be possessed by the being, to which the Entity agrees. Professor Pericles believes he has gained ultimate power (due to his growth in size and appearance), but the Evil Entity kills Pericles and mutates his body into a squid-like monster. The Entity then assumes control of the Kriegstaffelbots and summons other evil Anunnaki, who proceed to offer the townspeople for the Entity to consume. When Scooby destroys the sarcophagus, the Entity is killed and a vortex sucks everything in, except for the gang, then explodes. The gang find themselves in a new version of Crystal Cove and Earth itself. After some strange encounters, Mystery Incorporated realizes that all the evil ever caused by the Entity has come undone, thereby changing history.