Emir's resignation hits the clinic like a bombshell. While Efsun does her best to keep Emir in the clinic, an unpleasant surprise awaits her. Efsun's ex-boyfriend, Ali Bıçakçı, is at the symposium attended by the clinical team. With Ali's arrival, all attention turns to him. While Efsun tries to prevent her relationship with Ali from being exposed, Emir tries to cope with the feeling of jealousy he experienced for the first time in his life. Is it really Ali Bıçakçı, whom he is jealous of, or...?

When Ali Bıçakçı starts working at the clinic, it causes tension between Kaya and Pervin. Emir, on the other hand, has fits of jealousy because of the closeness between Ali and Efsun. This will speed up the negotiations with investors and clinics. Meanwhile, Efsun tries to find other ways for Emir to stay at the clinic. Emel Müftüoğlu's arrival at the clinic as a patient complicates matters.

Emir decides to stay at the clinic, but he has one condition: Efsun's departure. Although Efsun decides to fight in the clinic, Emir's outburst deeply hurts her. Emir thinks that Efsun and Ali are lovers. Efsun's attempt to arrange an operation for a patient who wants to have a face transplant will cause confusion in the clinic and break the ice between Emir and Efsun.

Emir decides to stay at the clinic. When Efsun learns that Pervin has an operation in Istanbul, this causes her to take a stand against both Emir and Pervin. In Adana, where Emir and Efsun go for an interesting case, an action-adventure awaits them.