When Leanne's ex-husband Peter is charged with the murder of his friend and boss, once the truth comes out about Peter's possible motive in the killing, Matlock despises his ex-son-in-law more than ever.

Matlock witnesses a robbery at a convenience store, but when things start happening that make him look like he's losing it, including messing with his papers, sending him to the wrong parties, and submitting phony pictures of his hind end to the papers, Matlock begins to realise that someone is trying to set him up. He, Cliff and Conrad begin to go through some of his old cases, trying to figure out which recently released killer is out to get him, but everyone they think of seems to have an alibi.

Matlock invites homeless man Lenny to live with him while trying to find out if the archbishop was meant to die in a plot including an ex-football player, his wife, her lover, and the mafia.

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Matlock realizes he has become a witness in a murder case involving two theater actors and an unhappy husband.

Matlock reluctantly agrees to host a reception for his goddaughter's wedding at Leanne's prompting, but when one of the best men is murdered after the bachelor party, Matlock agrees to defend the brother of the bride when he is accused of murder. The case is hindered by cheating lovers, a bad history between the victim and the accused, and an increasing number of houseguests at Matlock's home, none of which were invited.

Matlock is the unlikely witness when a boat blows up killing Judge Michael Sterns. Had it not been for Ben's sea-sickness, he would have been on the boat. Convinced that someone was out to get him and not Judge Sterns, Matlock, Cliff and Jerri take a look through some of Ben's old cases to find out who did it, and Matlock takes on the case of the man accused of the crime, a former lawyer who had been disbarred for jury tampering exactly five years earlier.

While Cliff, Jerri and Billy plan to throw Ben a surprise party for his birthday, Ben goes to the city to pick up barbecue. While there, his car breaks down, he's mugged, the phone eats his last quarter ... and by the time he is rescued by activist Stan Johnson and returned to his car, it's half-stripped and they've stolen his barbecue. Matlock is very impressed by the young man, and when he's accused of trying to kill the landlord of the apartment complex he lives in, Matlock steps in to defend him and to stand up to the landlord, who is a very respected man in the legal community.