Frank Hellner, a lonely paraplegic, takes part in a top-secret project -- allowing an "inorganic human," or robot named Valerie, to be his companion for a week. The experiment goes awry when Valerie, unable to control her programmed emotions, becomes jealous and threatens the life of Frank's physical therapist and close friend Rachel.

A mentally challenged boy named Howie is the last unaffected person in a small town overrun by a strange madness. Miners unearth ancient parasites, in the shape of worms, that attack the brains of their hosts. While the infected townsfolk lose all their inhibitions, Howie must save his sister Sheila, the only person who truly cares for him. Deprived of Sheila's guidance for the first time in his life, Howie struggles to evade his maddened neighbors and destroy the parasites. In the process, he becomes a hero to the whole town.

Since Dr. Martin Nodel is the most brilliant geneticist in the world, the students and staff at the university are willing to put up with a few eccentricities -- unlike his son Paul, who gets impatient with his father's behavior. However, Dr. Nodel's behavior goes beyond eccentric after he unveils his research into introns, mysterious genetic material which he believes hold the code for future evolution. After a successful animal test, Nodel secretly tries the formula on himself, with amazing and disturbing results. As his intelligence begins to grow, so do scales on his hands, strange markings on his body, and a mysterious hole in his back. And he seems to be getting instinctive messages telling him to bring 'subjects' to a remote wilderness location. When he arrives there, accompanied by six students including Paul and his girlfriend, he finds a group of heavily armed soldiers and the key to unlocking a mystery that goes far beyond human science.

Charlie Bouton's (Tom Butler) last project for the Innobotics Corporation was a sexy female companion robot named Valerie 23. It almost put the company out of business when it went berserk and attacked someone. So, his bosses are skeptical when he and scientist Melburn Ross (Michael Shanks) introduce Mary 25 (Sophia Shinas), a nanny robot adapted from the earlier model. In order to overcome their doubts, Charlie proposes letting the robot take care of his own children - a move that is met by serious resistance from his wife Teryl (Cynthia Geary) and his children Brad and Brook. From the beginning, there are problems. Unlike the human nanny, Carmen, Mary doesn't grasp the subtleties of child care and Melburn must fine tune her. But, Melburn sees that the problems go beyond Mary's programming. Charlie is smitten with his inorganic creation and has begun to abuse Teryl - a woman with whom Melburn was once romantically involved.