The 1979 murder of a schoolteacher who was stabbed to death in a wooded area is reopened when the victim's bloodstained jacket is found stuffed in a tree trunk with a happy-face key chain in a pocket. The case was originally investigated by Jeffries when he was a rookie detective.

A father pushes a registered sex offender off of a building and threatens to kill a different sex offender each day until the cold-case unit solves his son's 1987 rape and murder.

The 2005 murder of a longshoreman who accidentally became involved in a human-trafficking ring run by the Russian mob.

In the fourth season finale, a hostage situation arises when the entire team is held captive while they're investigating the 2006 killings of a family who had just moved into a new house.

The team re-opens the 1989 case of an unidentified Jane Doe when she dies in the hospital, after being comatose since the day she was shot 18 year ago.

The team re-opens the 1999, 2001, and 2003 pipe bombing incidents that killed two and blinded one victim. The serial bomber is still on the loose and ready to strike again as he missed his latest target.