Trying to do her part in Team Dai-Gurren, Nia decides to become a cook, but just before the crew have a taste of her dishes, Cytomander, the fourth member of the Divine Generals, launches an aerial attack on the Dai-Gurren. Simon leads the counter-attack on the Gurren-Lagann, this time accompanied by Yoko, who replaces a sick Rossiu.

One year earlier, Yoko starts working as a schoolteacher on an island until she learns of the situation at Teppelin and returns to break Simon free. Once again reunited, Simon and the members of Team Dai-Gurren launch themselves into space to protect the Arc-Gurren from the enemy forces, now accompanied by Viral as co-pilot of the Gurren-Lagann.

After finally transforming their flagship into the Super Galactic Gurren-Lagann, Simon and his friends successfully fight back against the enemy. When their enemy starts to use their own memories and desires against them, Kamina reappears to help.