When Will Preston, a western movie star and one of Quincy's idols, is found dead Quincy clashes with Lt. Monahan over what really happened to cause his death.

Quincy is asked to cover for a GP working in a small community north of Los Angeles. There he becomes involved in a case of medical negligence after the death of a local man.

Quincy and Sam have to stay late, going over work that was completed by a Medical Examiner who, it turned out, wasn't qualified for the job. This makes Quincy miss yet another date with Lynne, his current girlfriend. When they do get together she proposes to him. He turns her down because he remembers how he treated Helen, his first wife. He was always working and never spending enough time with her. Later he feels guilty and decides to go and see Lynne and propose to her himself.

Quincy investigates the death of a teenager who smoked marijuana treated with a chemical that stimulates plant growth.

Quincy has to autopsy a man who died at the county hospital. He is amazed at the ability of the Dr. who tried to save him. It turns out though that the patient was originally taken to a different hospital that turned the ambulance away because the man did not have any insurance.

Quincy visits the hospital and, after seeing the same thing happen again, decides to make sure that the owner, Dr. Rollins, does not get to buy another local hospital and run it the same way.

After Quincy's traces an old man's death to his son's physical abuse he is faced with a similar case involving the exploitation of two elderly women by their unscrupulous nephew.

A nurse seeks help from Quincy when a heart-attack victim dies at the medical center where she works. Her boss and the two doctors involved want her help in trying to cover up the true circumstances of what happened. She fears for her job if she doesn't help and her career if she does.

An explosion kills a man who is discovered to be the advance scout for a hitman. Quincy is in a race against time to find the assassin and thwart the plot to kill a government official at a hotel convention.

Sam and Quincy are attending a job fair for students when a woman falls down an escalator, just after shouting at someone who has been following her. While she is in hospital it is discovered she has a severe case of posttraumatic amnesia. A high price assassin is caught in her hospital room not long afterwards and leads to even more interest in who she is and why someone would want her dead.

Quincy and Janet finally get some time off and go on a weeks cruise. They are looking forward to some rest and relaxation together.

Before long their holiday is interrupted. Quincy is visited, late one night, by the captain. One of his crew has been murdered and he would like Quincy's advice. The murderer is caught but he has died before the morning and an autopsy reveals that he could have died from an infectious disease. A disease that could already be spreading throughout the ship!

With the cruise ship being prevented from docking at any of the islands in the area it is down to Quincy and Janet to find out exactly what the disease on board is before everyone on the ship finds out and starts panicking.

Quincy has to testify in the court of a small town. The witnesses in the case are pressurized into lying and Harry Muller, a bullying murderer, goes free. Within half an hour of the court case having been dismissed Harry Muller is found dead. The six men in the shop where he died all say they killed him, firing one shot each from his gun. The police chief is happy to call the death self defense but Quincy knows that it was murder and insists he will find out which one of them really killed him.

Michael Moroshima, a cop working undercover with the Asian task force and Sam's best friend, is killed while listening in on a deal between the Yakuza and the Mafia. Sam explains to Quincy all about the Yakuza and the Japanese code of honor that means his friend's father will try to find his son's killer and exact revenge. Sam tries to prevent this from happening but finds himself getting into deeper trouble himself.

Quincy and Emily's wedding is fast approaching and there are many things that still need arranging. Emily has brought in Winslow, a wedding arranger to help. While the wedding arrangements are proceeding a body comes into the coroner's office, an old man who died of natural causes in a rest home, just after his 65th wedding anniversary. After the autopsy the wife of the deceased man, Edna, comes in to see Quincy and tells him that she killed her husband.

Emily calls off the wedding when Quincy fails to make it to the rehearsal, the last straw as far as she is concerned. Quincy seems to be more interested in the tales Edna has to tell about her husbands' death. Was it murder as she claims or are her statements just the ravings of a mad woman?