Brain plans to take over the world by creating a voice mail system that will tie up everyone on the planet long enough for him to take over. In order to do this he needs money. He decides to get it by getting a job and then staging an accident in order to sue the company.

A successful modern artist is born and it's Pinky, trying to help fund Brain's new plan.

In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.

After the Earth gets the power of speech from his Silitronlinguifactor device, Brain comes up with a new plan.

After getting a glimpse of his future, Brain abandons his attempts to take over the world and gets a job as a ski instructor.

Brain sings about past and present world leaders' failures.

Brain's latest plan is a conspiracy theory about why he is not ruling the world.

Brain creates a cloning machine and plans to clone himself in order to create the best Celtic dance troupe the world has ever seen.

Brain assumes the identity of Briany Jack, a hippie leader, and tries to create a peace chain to send a subliminal message.

Brain enters Pinky's family in a contest to win $25,000.

Pinky and Brain masquerade as a mother and child star respectively to get money needed for the next plan.

The mice and Snowball search for the one who spliced their DNA, Dr. Mordough, thinking he's responsible for all this. But it turns out to be his cat, Precious, and time is running out.

A special of highlights of their career is on the air, but it's really all a ruse so Pinky and Brain can hypnotize the viewers.