Brain hatches a plot to hypnotize people, but he needs white crab meat to succeed. In order to get the crab meat, he takes a submarine to the wreck of the Titanic. Unfortunately, the CIA spots his sub and orders its destruction.

Brain uses an enlarging ray to make himself and Pinky four hundred feet tall. With Pinky dressed as a Gollyzilla, Brain stages a fight to make himself look like hero. But then the real Gollyzilla shows up.

Pinky and Brain perform a song about the brain.

Brain hears that a space probe is about to be launched. On the probe is a plaque with a representation of man and woman. Brain changes the plaque to make it appear that he rules the world. Aliens discover the probe and take Pinky and the Brain to their planet where they honor them just like they are "honored" on Earth.

Brain develops a special pair of dentures that can produce a smile that can hypnotize anyone who is not wearing a special pair of sunglasses. In order to take over the world, he needs people to see the mesmerizing smile. He figures that he needs to get on TV and in order to do that he has to become a celebrity.

In Victorian England, the Brain realizes that he can take over the world by becoming president of the "Pompous Explorers Club". since the position usually leads to the Prime Ministership of England. In order to become president of the club, he must make it around the world in seventy-nine days.

Brain plans to melt the ice caps with the Hubble Space Telescope once he buys everything higher than the 39th floor.

Brain hopes his inter-galactic pen pal, Zalgar, will help him take over the world. But it turns out Zalgar likes to snack on brains.