Experiment #375 has been activated; a phantom-like experiment that can inhabit and animate inanimate objects. So when it gets loose in the family's house, it inhabits Lilo's toys and creates all sorts of mess, for which Stitch gets the blame. Can they catch the real culprit, or will Stitch be blamed for everything?

Lilo is upset when Mertle gets a nice-looking fancy hairdo. But when she encounters a hair-eating experiment, Clip, she decides to get her revenge on Mertle by placing it in her bedroom with the plan of ruining Mertle's hair. But the plan runs amock and the experiment eats Mertle's mom's hair instead, and now the experiment is loose on the island. Now Lilo and Stitch must track down the experiment before everyone goes bald!

Lilo and Stitch have captured a new experiment, #254. He is insanely cute too, and charms all of Lilo's friends. Stitch is jealous though, so at the first chance he gets, he lets Gantu capture him.

As luck would have it, 42 hours after the experiment's activation, Mr. Stenchy releases such a foul stench, the area he releases it in is uninhabitable for decades. But without knowing of when Mr. Stenchy was activated, how will Lilo and Stitch save him before he releases the smell?

A bird has discovered a strange blue ball in her nest. After deciding she doesn't need it, she discards it into the river running below her tree. It turns out it's #520's pod, and it activates. Now the experiment is wreaking havoc over the island with it's huge behind by bouncing and shaking the ground. So, Lilo and Stitch must capture it, but Gantu is on it's trail too.

Mertle has got a new dog; Gigi. Little does she know, it's really Experiment #007, a dog that can keep everyone in the neighbourhood awake with it's loud yapping. So, Lilo and Stitch must protect it from Gantu, but have to go to a dog show to do it.

Experiments #501 and #502 are both activated at the same time, a water sprayer and a lava sprayer. Unfortunately, Lilo and Stitch are having some problems with each other, and soon decide to split apart, with Lilo teaming up with Pleakley, and Stitch teaming up with Jumba. Can the 2 capture the experiments without their partner?

When Experiment #601 is activated, things are looking bad, as he is beating up the islanders. Stitch is ready for it, but when he eats the combination of a left tennis shoe and macadamia nuts, it creates a toxic poision, which erases all of his super abilities. Now Lilo has to retrain him from scratch, but Stitch doesn't like the idea.

Stitch has been recently very successful at capturing and repurposing the Experiments, but it's gone to his head. He thinks he's too good for everything and is being a royal pain.

But things are set to change when Pleakley goes into Jumba's ship and sees an experiment pod with the number '627' on it. Jumba has been making a new experiment. Luckily, it's in containment. That is, until they leave the ship and it escapes! Now it's employed by Gantu and Stitch wants to prove he's better than it. But he just gets beaten, and as 627 can't be turned good, Lilo and Stitch are in trouble...

In a trip to the observatory, Lilo and Stitch overhear Cobra telling an astronomer about a huge asteroid heading towards Earth. Lilo and Stitch go around Kauai telling the people to evacuate with them onto their ship. Stitch also warns his cousins. However, only 6 Experiments - Digger, Swirly, Hammerhead, Sparky, Spooky and Kixx - and a surfer from the beach arrive at the ship. So, Stitch comes up with a new idea; Digger will drill a hole to the center of the asteroid, it can be smashed. Things seem to be going to plan, but they soon find out something lives on the asteroid, and their plan comes crashing down.

Experiment #602 - Sinker

Lilo is having high hopes for Keoni and his sailboat entry in a regatta, until his boat is sliced in half by Experiment #602. Soon Lilo, Stitch, Jumba and Pleakley are stowaways on a cruise ship. So while Pleakley is fascinated by shuffleboard, and Stitch digs into the buffet, Lilo must find the ship's Captain and warn him about Experiment #602.

Experiments #010 - Felix and #010.2 - Oscar

Experiment #010 is a neat-freak, named Felix. So when it won't stop cleaning things, Jumba reprograms it to Experiment #10.2, Oscar. However, the newly programmed Oscar doesn't work quite as it should.

Experiment #323 - HunkaHunka

Keoni is in love with Pleakley, and Lilo thinks Experiment #323 has been activated and is loose. So, they go after it, while it causes chaos and makes people all over the island fall in love with the first people they see.

Experiment 089: SKIP

Lilo's desire to hurry and grow up is immediately satisfied when Skip, experiment 089, arrives and ages her up to a 17-year-old and then a 27-year-old. Lilo soon realizes she wants to be age 7 again because she misses out and ruins the future. She must figure out how to "reset" herself.

Experiment 285: LAX

(Crossover with RECESS)

The gang from Recess are on 'holiday' in Hawaii! But experiment 285 is on the loose, causing Vince, Mikey and Stitch to abandon any and all forms of work. Can Lilo stop 285 and Hamsterviel's new experiment locator satellite without Stitch, or will Gantu finally succeed in catching an experiment?

Note: This episode first aired on Disney Channel on September 5, 2006 at 5 a.m.