While exploring some Pyramids in Mexico, Jackie gets a call from El Toro. He needs Jackie's help dealing with the legendary El Chupacabra.

The Dark Hand seeks out the next Demon Portal at Fenway Park. Hsi Wu the Sky Demon, flies out of the Demon Netherworld but it's right in front of the girls bathroom door, and his tail snaps of as Jade tries to close the door. Hsi Wu disguises himself as one of Jade's classmates and they become friends. But once Hsi Wu learns that Uncle put a Chi Spell on his tail, an angered Jade uses some of the Talismans to confront him.

Before Bai Tza can use another flood, Uncle uses a gourd from one of the Immortals to seal her away again. Unfortunately, Jade steps too close to the chi spell and is dragged into Bai Sa's portal. Meanwhile, the Demon Sorcerers communicate with and confront Shendu. In order to escape punishment, he promises that all seven of the Demons can use his own Portal – the only one left – to come back to Earth. A race against time ensues as the Chans work from both sides to both recover Jade and close the last portal for good.

Jackie finds a highly valued cat statue. Anyone who is scratched by it is magically transformed.

Forced to steal it back for a gangster when Jackie is tossed into a jail cell, Jade is able to retrieve the statue, but gets scratched by it in the process.

Uncle had been researching into the Cat’s legend, and says that the cure lies within. Jackie soon has an epiphany, and decides the Cat is too dangerous to be in a museum. So he smashes the statue, thus releasing a purple-colored gas that cures Valmont and Jade. With that, Jackie then realizes that “The antidote lies within” meant that the antidote was inside the statue itself (and not within a person, despite what he thought at first).

Captain Black is ordered to remove the Talismans from Section 13. So they're force to a new place for them. Daolon Wong tries for the Talismans, unaware that all the powers of the Talismans have been transferred into the Amazing T-Girl.