Il medico di bordo della Odyssey, Max Bankman, fa conoscenza con il capitano Massey e la sua equipe medica, Avery e Tristan, mentre affronta delle crisi a diverse miglia dalla costa.

Mentre Max, Tristan e Avery affrontano le loro relazioni, la ciurma respinge le avances dei passeggeri; con il desiderio crescente e le malattie che si diffondono rapidamente, Max e la sue equipe si affrettano a riportare l'ordine.

Plastic Surgery Week on The Odyssey brings new faces and fresh features to be carefully maintained by the medical team. Meanwhile, when the owner's wife comes on board, Capt. Massey must juggle charm and skillful dodging to sidestep her advances.

During a week dedicated to wellness, The Odyssey ironically finds itself overwhelmed by a surge of ailing patients. Meanwhile, Tristan's new romance sparks jealousy, and Capt. Massey must bring the ship to safety in the midst of a hurricane.

It's Halloween on The Odyssey, featuring a high-stakes costume contest; but when a zombie-like illness plagues select passengers, the festivities take a dark turn. Meanwhile, Avery and Max embark on a rescue mission.

When a wealthy family charters The Odyssey for a weeklong wedding cruise, all eyes are on the "bridezilla" as she wreaks havoc on board. Amid the chaos, love and lust manage to find their way through the air with sparks flying among the crew.

Bears, otters and cubs on board can only mean one thing: It's Gay Week on The Odyssey. As Max, Avery and Tristan navigate their relationships, Capt. Massey's brother arrives with an unexpected guest.

It's Quakers Week, and the ship is bustling with guests obsessed with a quirky trend taking over the cruising industry: rubber duckies. As the voyage unfolds, Avery receives unexpected news.

Max and Avery are at a crossroads as Avery faces a difficult pregnancy decision. Meanwhile, after Munroe is bitten by a shark, the Odyssey takes a dangerous detour to rescue a sinking boat, where a mysterious new passenger catches Max's eye.

Amid a power outage, Max, Tristan, Avery, and Brooke struggle to treat shark-inflicted wounds. As romantic tensions flare between Max and Brooke and new sparks fly between two former flames, the team must perform an emergency operation.

It’s Casino Week aboard The Odyssey, and unexpected guest Athena Grant suspects two passengers are targeting the ship’s vault. Enlisting Max’s help, Athena raises the stakes in a dangerous game where not everyone will end up with a winning hand.

Tristan strives to prove himself to Avery, while Captain Massey is shaken by shocking news. Meanwhile, Sophisticated Ladies Week brings a disruptive passenger onboard, while the crew navigates the delicate care of a terminal patient.

Spring break hits The Odyssey as three college “vixens” set their sights on Max. Meanwhile, Tristan faces his drinking problem while other passengers’ struggles keep the medical team on their toes.

Cheerleaders aboard The Odyssey bring nostalgia, but when Avery receives troubling news, Max and Tristan step in to support her. Meanwhile, Tristan explores sobriety while Captain Massey’s stress takes a physical toll.

Crew week on The Odyssey sends Max back to his hometown for answers, while Tristan reveals Avery's secret to Vivian. As Munroe fights a parasitic infection, Avery pressures Rosie to face a medical condition she's been hiding.

Mayhem ensues on The Odyssey when high-profile book tours for trad wives and sex-positive groups are double-booked. As tensions rise, Max, Avery and Tristan provide medical attention to both VIP authors.

After Max’s declaration fractures his relationship with Avery, he leaves the ship and finds himself caught in an earthquake, which triggers a tsunami warning. With The Odyssey forced to leave port, Max races to return before it’s too late.

When Max's transmission goes silent, he and Barry seek refuge in an abandoned church while Tristan takes charge of The Odyssey. With time running out, Avery leads a high-stakes rescue mission to find Max.