Shinra, a boy living in a forest with mysterious powers, calls for Ginko, The Mushishi, to help him with his problems. While Ginko is staying with Shinra, he tells him all about Mushi and his powers. Later on, while walking in Shinra's house at night, Ginko finds a Mushi... But this isn't an ordinary Mushi, it's Shinra's grandmother!

Ginko hears a rumor around town that a man is has prophetic dreams every once in a while. He suspects that Mushi are living in his dreams. He gives the man medicine to keep them under control and says he will come back when he has used about all of them. When Ginko returns, the village is deserted and torn up. Ginko finds the man alone in is house. The man then tells him about what happened while he was away.

On a rainy day Ginko takes a rest from his travels and comes across a man named Kourou who seems to be obsessed with a rainbow. To pass the time Kourou reminisces in his past, with the events which led to him pursuing rainbows whenever they appear. Ginko explains to him that the rainbow which he is searching for is actually a Mushi known as "Koda" but there seems to be more to it.

While on his journey, Ginko stumbles upon a town which has yielded a great crop this year, thanks to their ancestors. However, it is said that someone must be sacrificed in exchange. Ginko finds this peculiar and decides to investigate further, by going to see the village "Saishu-sama" (chief mourner) who may have something to do with it.

"Don't let yourself be blinded by fear and anger. Everything is only as it is..."

A boy named Yoki, who's able to see Mushi, was found in the woods by some mysterious lady named Nui with only one eye. It turns out that Yoki was travelling with his mother when a mudslide crushed his mother and he was left all on his own. Yoki's leg later heals itself however he doesn't seem to have anywhere to go so he stays with the Nui and begins to learn some things about the Mushi known as "Tokoyami".

"When all are sheltering within, there comes an imitation of spring. Linger in bliss for too long and your flesh will soon be frozen..."

Caught in a blizzard, Ginko is decides to look for shelter and finds a home where the owner, Suzu allows him to stay the night. The next day Ginko sees a boy, Miharu who seems to be fascinated by Mushi. Ginko learns that Miharu once disappeared into the mountains in the winter and then suddenly came back in spring, able to see Mushi. Miharu has been repeating this since and it may be caused by a "Harumagari" so in the end, Ginko decides to teach him more about Mushi.

Seijirou is fascinated by the stars and enjoys stargazing. One day he was by the riverbed with the village nanny Fuki when she notices a string coming down the sky and as she tries to pull all of a sudden she disappears, right before Seijirou's eye. Ginko is travelling through the mountains and is being followed by a peculiar girl. It turns out that it's Fuki, who has been exposed to a strong Mushi presence and can't be seen by anyone.

Ginko arrives at a secluded place, to meet an old acquaintance, who seems to be in charge of a large volume of archival, confidential text. Ginko is allowed to read it, and discovers it is the work of Tan'yu, a writer. Tan'yu is the descendant of the Karibusa family, being born with a black mark on a part of their body.

"Give birth to me once more. I want to meet you once more. I want to see this beautiful ocean once more..."

Ginko arrives on an island asking about the so called "Rebirths" but to no luck. At night he later meets a peculiar lady who happens to be able to see a strange light in the sea and she ends up inviting him to her home. She later explains to him what "Rebirths" are; when a person is about to die they can be taken deep inside the Ryuugu, where they are reborn.

"Build a fire - night comes... Light a fire - darkness comes... Hide the fire - flames arisen from corpses creep in..."

Ginko meets another Mushi-shi, which happens to be a young lady called Yahagi and surrounding the village she lives in is a new variety of Mushi growing on the mountain's fields. It's becoming so bad that the village people are at risk and as a last resort they plan to burn the entire mountain but Ginko doesn't think that this is the right option.

A powerful mushi appears during an eclipse, drawing other mushi to form a huge shadow that blocks the sun over a small village. Looking for clues about the mushi, Ginko meets a child who is afflicted by a strange disease that manifests itself when she is exposed to sunlight, and it does not take long for him to find out that both facts are related.