Shinra, a boy living in a forest with mysterious powers, calls for Ginko, The Mushishi, to help him with his problems. While Ginko is staying with Shinra, he tells him all about Mushi and his powers. Later on, while walking in Shinra's house at night, Ginko finds a Mushi... But this isn't an ordinary Mushi, it's Shinra's grandmother!

On silent snowy nights, when no sounds can be heard, many people go deaf in one or both ears. The doctors can't do anything, so they think it might be paranormal. Ginko looks into some of the villager's ears and he tells them that the cause is a Mushi called "Un". After dealing with their small problems there is one more person who has lost sound in both of his ears and his condition is very different than the other people's, as he has also grown four horns on his head.

Ginko is on another adventure as he is brought to a very peculiar island, by a young boy Nagi. Ginko is taken to see a girl, who the island inhabitants refer to as "Ikigami" and is said to be able to perform miracles however Ginko discovers that there is more to this.

Ginko is waiting along the sea shore, for a transport to get him across the bay when he meets a man called Shirou, who lost his wife under strange circumstances. Ginko seems interested and decides to listen to his story about how he lost his wife in a swarm of sea snakes, during fog. Ginko later comes back with information on the Mushi that caused the bizarre events.

Some kids enter Adashino-sensei's shed and find a lot of strange things, but there's one thing in particular that interests them. It's night and Adashino-sensei is called upon to look at one of the kids, a girl who has become bitterly cold, and the cause is a mysterious ink stone she touched. Luckily for Adashino-sensei, Ginko is passing through the village, and he shows him the ink stone, which he identifies it as a "Kumohami".

Just managing to cross the treacherous Kazura Bridge, Ginko meets up with a man on the other side who takes him to meet a lady called Hana, who fell from the same bridge 3 years ago. Even though Hana survived, all she does is sit under the sun and nothing else and nobody seems to know what's wrong with her. Hana is feared to be a "Tanimodori", which are people whose minds and memories are wiped clean and they die on the night that the "One Night Bridge" shows up. From the info gathered Ginko knows that Hana is possessed by a Mushi called a "Nisekazura".