The strong friendship between Lew Wickersham and Mannix melts into a violent and deathly feud. The bitter battle begins when Mannix launches an investigation into the theft of a highly secret formula for the development of a laser ray. Stolen plans and sabotage involve Intertect and their agents.

The two paths of the case meet at the water's edge.

Mannix is called to testify against an ex-con he sent up, but his time suspects a frame.

A colleague's death leaves Mannix with the evidence he was murdered for.