Scott Bakula starts off with a discussion on the third season story arc, the Xindi Saga, and how that pushes the series and the development of the characters in it. Phyllis Strong, André Bormanis, Mike Sussman, David A. Goodman. Brannon Braga, Rick Berman. Chris Black & David Livingston talked about the influences of the 9/11 tragedy on this story arc. There was also pressure to make the show more "edgy" and the lack of a complete roadmap for the story arc when the season started. Manny Coto talks about how he influenced the arc through the season and satisfied Brannon Braga's desire for the right alchemy in the writer's room.

Jolene Blalock begins this discussion and says she was burnt out by the third season, but still found the work stimulating. John Billingsley, Anthony Montgomery & Dominic Keating continue the discussion of the change in direction during Season Three and the lack of support from UPN at the time. Conner Trinneer discusses how 9/11 affected him and Phyllis Strong believes it had an impact on his third season performance. John Billingsley laments about the changes in Archer's character during the season while finding many of episodes to be exceptional. Linda Park talks about the advantages of serialized storytelling and that allows characters to grow and change. David A. Goodman agrees and compares the season to the Dominion War during Deep Space Nine. John Billingsley also agrees but also notes that "standalone" episodes were done to allow alternatives to be possible. Manny Coto talks about his episode "Similtude" and how it stood alone, but supported the arc.

Brannon Braga starts the discussion thinking Season Three was going to be good. André Bormanis and Manny Coto speak to how the Xindi were realized in expensive digital effects of the time. Dan Curry, Ronald B. Moore and John Billingsley discuss some of the shortcuts taken with the visual effects. Randy Oglesby remembers his performance as "Degra" as well as his time playing in other Star Trek episodes. Scott MacDonald (who played "Dolim") recalls how he interacted with Randy which came to be because they worked with each other for years. Manny Coto and Brannon Braga discuss the potential of killing Archer at the end of season three and the cliff-hanger they ultimately decided on.

Manny Coto talks about the construction of the fourth season as a series of mini story arcs that would tie more directly into the Star Trek canon. Brannon Braga was burned out on Star Trek and was ready to move on. Mike Sussman recollects the brainstorming with Manny Coto in between the third and fourth season. André Bormanis recalls that Manny Coto really wanted to do more about the creation of the Federation. Garfield & Judith Reeves-Stevens spoke to their time as writers brought in by Manny Coto.

Larry Nemecek notes that Enterprise had to get good ratings. He notes that the episodes where good, but the ratings were not that good. Judith & Garfield Reeves-Stevens mused about the signs that the show was ending. Mike Sussman noted that the budget for season four had been reduced. He notes that was mitigated by amortizing the cost across multipart episodes. This gave rise to three episodes on Vulcan, three about the Augments, three about the Andorians & the Romulans, two about the mirror universe and the final arc about the xenophobic movement on Earth at the time the precursor to the Federation was being negotiated. Manny Coto talks about a potential of William Shatner being on Enterprise via something involving the Mirror Universe. Mike and Denise Okuda noted how wonderful the original series sets (reproduced for the Mirror Universe two-parter) are. Manny Coto notes that he wanted to do more Gorns and Tholians. Several cast members comment on season four.

The effect of UPN on the end of Enterprise. Several cast members and crew comment on the "let down" that comes with the end of the show. Jolene Blalock comments on the last episode and her disappointment with it. Conner Trinneer was happy with it. Manny Coto muses about what he would have liked to explored.

Rick Berman talks about the job of orchestrating Star Trek from The Next Generation through Enterprise. The production crew and the Enterprise cast comment on the end of the era.