Naruto’s and Sakura’s combined skills force Kakashi to use his Sharingan right off the bat. Naruto masterfully unleashes his jutsu one after another.

Sakura treats a critically ill Kankuro. After extensive training she’s now a full-fledged Medic Ninja, and Sakura amazes everyone with her sure, steady hands.

Breaking the five-seal barrier set off a trap, which now has Team Guy battling amazingly accurate copies of themselves. Back at the Akatsuki hideout, Deidara and Sasori struggle to take the Nine-Tail Jinchûriki.

Sakura hurries to get to Naruto with Granny Chiyo, who is suffering from the poison. The members of Team Guy rush to assist Team Kakashi. Meanwhile, with all preparations complete, Kakashi reveals his Mangekyo Sharingan.

Sai receives a chilling glare from Sasuke's Sharingan that frightens him. Sai gives Orochimaru a bundle with information about Konoha's ANBU. Yamato gives Sakura and Naruto seeds with his chakra that enables him to track them inside the lair, and reveals that he was able to track Sai because he put a seed in Sai's clothing and food during the visit to the hot springs. Kabuto locks Sai in a room, and the boy summons a bingo book from scrolls he carries. Yamato uses a jutsu to open a tunnel into Orochimaru's hideout, and he, Naruto and Sakura travel to Sai's room undetected.

After the peformance of the forbidden jutsu, Hotaru is horrified to see the damage the jutsu has done. Shiranami then notices the forbidden jutsu overflowing with chakra and the fact that it would destroy itself along with Hotaru. While Naruto chases the fleeing Shiranami, Utakata tries to save Hotaru using the hidden power within him. Can Utakata save Hotaru?

The Akatsuki Leader, Pain, begins his invasion of the Hidden Leaf Village. The Leaf ninja assemble to protect Naruto's whereabouts, but when Pain targets Iruka, Kakashi must face off against him.

Might Guy recalls their "visualization" training with Lee in order to avoid learning the Drunken Fist and forgetting an incident which Might Guy apologizes to the restaurant owner with humiliation. Lee, who is determined to train to be stronger than Naruto, follows Might Guy's orders and resemble animal fighting styles which represent on a restaurant menu. However they failed, until they tried on training on a moving boat. Like Guy who has seasickness, Lee also suffers from seasickness but he uses it to balance the boat which resembles exactly as the Drunken Fist fighting style. Guy lately realizes that Lee is also aware of the restaurant incident and Lee was only protecting Guy from a drunk man which causes the restaurant to be totally damaged.

Tenten remembers when she was little and how she really wanted to become like the legendary Tsunade. She finds out through hard training that she won't be capable of the strength Tsunade has. She also finds out that she won't be suitable to be a medical ninja for her poor chakra control. But at last, she discovers that she has the ability to summon ninja tools, thus creating her own style of fighting.

Naruto and Minato combine their powers to perform a Sage Jutsu attack on Obito.

Lee challenges Shira to a battle between taijutsu users!

As Ino and her team head toward an oasis, they are attacked by a team of Sand Shinobi comprised of Ameno, Shishio, and Kouji.

Tenten falls under the Infinite Tsukuyomi and wakes up in the Hidden Leaf Village. When Lee and Guy Sensei appear, Tenten is relieved to see that she is not alone. But her joy is short-lived, as both men act oddly and are dressed stylishly—just where has she been transported to?

Tsunade continues to read Jiraiya’s novel. Chunin- and jonin-level ninja have gone missing, and the Fourth Hokage, Minato, orders a search mission with teams of genin led by Guy and Kurenai. Kakashi’s Team 7 is also dispatched, but the hero Naruto Uzumaki, despite being the Hokage’s son, has the misfortune of being labeled a loser.

Naruto joins up with the rest of his comrades, and together they overcome the puppet attack. The masked man witnesses this and is convinced there is a future for the young shinobi. He promises to release the kidnapped jonin and begins to explain the truth, and the situation behind his motives.

Naruto wants to bring Sasuke back to the village, but Sasuke burns with a desire to bring Naruto down. Why is Sasuke so confrontational, and how did his feelings toward Naruto develop? The truth rises to the surface during Sasuke’s relentless attack. Where will this battle lead? Find out in the conclusion of the “Jiraiya Ninja Scrolls.”

Hagoromo sends the brothers to two battle-scarred regions left untouched since the fight with Ten Tails. He then announces that he will choose his successor depending on the outcome of their missions.