Nikita und Michael wollen gemeinsam einen Terroristen eliminieren. Als Alex beim Durchstöbern von Akten der Division erwischt wird, droht ihre Tarnung aufzufliegen.

Während einer Mission trifft Alex auf Irina, eine alte Freundin, und versucht ihr zu helfen. Doch Irina verrät Alex. Jetzt braucht sie selbst Hilfe.

Percy makes a move to take over the CIA, Alex goes rogue, and Michael gets trapped inside Division making him unable to help Nikita, who may have to pay with her life for helping Alex.

Birkoff tells Nikita and Michael that a black box file reveals that an international terrorist named Ramon, who has been taking credit for some serious political assassinations, now works for Division. This news upsets Nikita since she was the agent that captured Ramon years ago and turned him over to Percy. Amanda convinces Alex to kill Anton Kochenko, a man who used to work for Alex's father, and plans to let Ramon take the credit for the murder. However, when Nikita disrupts Amanda's plan, Amanda fights back by taking what Nikita loves most.

When a former undercover Division agent, Markov, is elected President of Uzbekistan, Nikita and her team decide to capture him during his visit to the United States.