Blythe earns the gratitude of the Biskit twins after defending them against a bully during gym, but ends up being forced from talking her other friends. Meanwhile, Pepper is inspired to use insult comedy as part of her stand-up comedy schtick, but takes it too far on Penny while being unaware of her sensitive feelings.

Suspecting that he has become too serious for his own good, Russell loosens up by creating an alter ego, dubbed "Fun Russell". Meanwhile, Blythe finds her friend Sue mimicking every aspect of her personality unsettling.

Blythe stumbles upon some keys belonging to her crush, Josh Sharp, and goes searching for him using Sunil's precognition. When he assumes she has gotten lost due to his own lack of faith in his psychic abilities, he enlists the help of his friends, along with larger-than-life parrot Esteban Banderas.

Blythe attempts to be the peacekeeper between Zoe and her old rival Madame Pom when arrives at day camp, all the while Penny Ling and Vinnie nearly destroy the shop while practicing for their new group dance routine. Likewise, Mrs. Twombly goes on a rampage in search of her favorite cleaning spray.

The pets suspect a Siamese cat visiting the day camp is preying on Mrs. Twombly. Meanwhile, Blythe encourages the Biskit twins to join their mathlete team after she overhears them using narratives of their daily life to solve complex math equations.

Zoe, temporarily bandaged due to an embarrassing pimple on her nose, asks Penny Ling to pass along her romantic feelings to her crush, Digby, during his stay at the day camp. Meanwhile, Russell hides in Blythe's backpack, wanting to pursue an education, but gets lost within the corridors of her high school.

Youngmee's Aunt Christie opens a confectionery store adjacent to Littlest Pet Shop, and the pets meet pet Buttercream Sunday, a hyperactive rabbit, who invites them to overindulge themselves on the sugar-filled treats located in Christie's pantry.

Surrounded by guilt, the pets try to prove Blythe's innocence after she is accused of sending Aunt Cristie's truck careening down the street while meeting Buttercream's alley cat friend, Sugar Sprinkles.

Vinnie accidentally falls into a dumpster while trying to catch a fly and is transported to the dump, where he encounters a rat that helps him get back to the pet store. Blythe contracts the common cold and can no longer understand the pets, so the pets try to cure her.

Russell, Zoe, and Vinnie, along with Buttercream, try to retrieve a recipe stolen from Blythe by the Biskits, who plan to use it for a baking competition hosted at Blythe's school. All the while, Vinnie has a vision of cakes occupying the world.

Zoe begs for Blythe to enter her in a reality television series based on a beauty pageant for dogs. What starts off as enjoyable starts to consume Blythe, who becomes driven by winning the pageant, much to the dejection of Zoe.

Sunil and Vinnie hear howling noises coming from inside the pet shop, and suspect that their friends have turned into werewolves. When Mrs. Twombly finds she has been outbid at an online auction for a highly coveted doorknob by her rival, Fisher Biskit, she takes Blythe and herself for a visit to his mansion to find its whereabouts.

Vinnie's tail falls off in an act of autotomy, and after a series of trials to find an adequate replacement for it, he is shocked to find that he becomes better at dancing without one. Meanwhile, Zoe and Pepper become rivals over the theme for a party meant for Penny Ling.

When Blythe gets accepted into the junior program at a fashion school, she, along with her family and friends from school and at Littlest Pet Shop, have to bode with the anxiety of her leaving.

Blythe must trade in her scooter for a sales kiosk in order for her to enter enter the International Pet Fashion Expo. Meanwhile, Roger's airline launches a "Pet Jet" service, with the pets using it to launch one of their largest fantasies yet.

Slow business prompts Mrs. Twombly to shoot a commercial for Littlest Pet Shop.

When Blythe fills in for Zoe's owners and accompanies her to a dog show in Paris, they suddenly find themselves smitten; Blythe with the city and Zoe with a mime artist dog named Philippe.

When Blythe and the pets travel to Shanghai to attend a ceremony honoring Mrs. Twombly as originator of Kung Fu Quilting, Penny Ling is reunited with family she never knew she had. Meanwhile the pets prepare a Chinese dragon dance to ward off spirits.

The results of DNA testing for two of the pets cause panic in the day camp. Meanwhile, Roger is laid off from his job as a pilot, and assumes the role of the Biskit twin's personal assistant and chauffeur instead.

An old nemesis shows up to defeat Blythe and the pets competing in the Carnival parade in Rio.

Russell tries to reconcile Sunil and Vinnie's friendship after an emotional falling out sparks between them.

Blythe stresses over the upcoming International Pet Fashion Expo when she is asked to do a photo shoot for Très Blasé.

At the Pet Expo, the Biskits sabotage Blythe at every turn, fueling superstitions over her entry. At the end, the Pets and Blythe are able to recover her stuff and exposes the Biskits' sabotage. The Biskits' butler confesses that they made him take part of their scheme. They fired their butler. The butler became a photographer. The Biskits are humiliated and expose for their crime. Blythe won the International Pet Fashion Expo. Pets got their faces at the magazine.

Russel challenges Vinnie and Sunil to entertain Mr. VonFuzzlebut, a raccoon who is placed at the day camp. As soon as he arrives, however, he enters a deep sleep, so Vinnie and Sunil must pretend to entertain him without Russell knowing. Meanwhile, Fisher Biskit encounters difficulty finding the reason behind Littlest Pet Shop's recent success, so he sends his daughters to find out.

Blythe meets another young lady at the thrift shop and dismisses her old companions; Vinnie becomes friends with an arachnid.

Blythe and Mrs. Twombly help a friend to make a showplace out of her rundown pet hotel, in spite of Fisher Biskit's determination to close down the place.

When Harold, an obnoxious groundhog, arrives at the day camp, Russell cannot wait for the day to end but is horrified to discover it never does.

When Blythe's dream of holding a Pet Fest in Downtown City has a chance to become a reality, she must race against time to pull it all together.

Blythe must race against time to make her dream of having a Pet Fest a reality.

Russell's dad moves in with him. Meanwhile, Blythe becomes friends with an elderly woman who wants Blythe to get to know her granddaughters.

Sunil's pursuit of happiness leads him through the city with the other pets. Meanwhile, Blythe tries to find her mom's journal after she loses it.