Monroe goes head to head with his new boss when he elects to operate on a patient with a deadly vascular anomaly. Meanwhile, Jenny Bremner returns to St. Matthew's from maternity leave to find the hospital changed - and her power diminished.

The neurosurgeon finds himself having to choose between trainees Springer and Wilson, who are both equally deserving of a place on his team, while cracks begin to show in Bremner and Shepherd's relationship. Monroe's patients include a woman with an aggressive brain tumour, which presents him with one of the most challenging cases of his career.

Shepherd has moved into Monroes. Springer has some legal issues.