Allison's old flame, Clay Bicks, appears at her doorstep moments after dying, unaware that he is dead. When he accepts the fact that he's dead and will never get to be with the woman he loved, he decides he's going to stay in Allison's house so he can at least be close to her. This upsets Joe, and Allison decides that something must be done to get rid of Clay. Meanwhile, Allison shares a bunch of odd dreams with Bridgette, except Bridgette's dreams keep coming to her in the form of cartoons for some reason.

Allison and Bridgette continue having the same odd dreams as Allison comes closer to figuring out what the dreams mean and how they relate to a series of shootings/killings. Clay still won't leave Allison's house, but his purpose eventually becomes clear and Allison's opinion of him changes. Meanwhile, Devalos' health is evaluated after a rush hospital visit and Scanlon's relationship with the mayor's liaison Lynn takes a turn for the worst.

Allison has unsettling visions about a father abusing his young son (Bryce Robinson), who in turn seeks comfort in a talking doll that may be delivering sinister messages to the child. Meanwhile, health issues rattle Joe as he takes on a looming project deadline.

Now that Allison's special abilities have been revealed to the public, everyone's lives have been turned upside down. Allison starts to have dreams about a boy who was kidnapped from a toy store, but is unable to turn to Devalos or Scanlon for help. She decides to call the company hired by the missing boy's family and makes an unusual deal with the company's investigator, Cynthia Keener.

Allison wrestles with a particularly disturbing dream, all while trying to figure out why a recently paroled convict is so intent on destroying her boss.

When Allison's brain tumor resurfaces, its aftermath could have life-altering consequences for her friends and family, on the sixth season finale of MEDIUM.

A series of mysterious fire-related deaths may be tied to Allison's dreams of a blaze. Allison must also think about where her professional career is headed, as Devalos starts thinking seriously about running for mayor.