Joe tries to prove that Allison's dreams are stress related by sending descriptions of them to law enforcement agencies. However, when one of her dreams matches a homicide in Texas, his attempt is thwarted.

Allison questions her powers when her old boss asks for her help in selecting a jury that will reinstate the death penalty for a murderer/rapist. This causes Allison to suspect that she has helped put the wrong man on death row.

Allison has a dream of a husband and wife committing a murder/suicide. D.A. Devalos introduces her to a friend of his, Detective Lee Scanlon, who's sister and brother in-law's deaths were also ruled a murder/suicide, and sees a connection. After learning about Allison's methods of investigation, Scanlon decides he doesn't want her help.

While Capt. Push lingers between life and death, Allison struggles to decipher confusing messages from the other side in an attempt to stop a serial killer before he claims his next victim.

Three girls are found murdered. Allison's visions connect Det. Scanlon with the case.

Allison's old flame, Clay Bicks, appears at her doorstep moments after dying, unaware that he is dead. When he accepts the fact that he's dead and will never get to be with the woman he loved, he decides he's going to stay in Allison's house so he can at least be close to her. This upsets Joe, and Allison decides that something must be done to get rid of Clay. Meanwhile, Allison shares a bunch of odd dreams with Bridgette, except Bridgette's dreams keep coming to her in the form of cartoons for some reason.

Allison and Bridgette continue having the same odd dreams as Allison comes closer to figuring out what the dreams mean and how they relate to a series of shootings/killings. Clay still won't leave Allison's house, but his purpose eventually becomes clear and Allison's opinion of him changes. Meanwhile, Devalos' health is evaluated after a rush hospital visit and Scanlon's relationship with the mayor's liaison Lynn takes a turn for the worst.

Now that Allison's special abilities have been revealed to the public, everyone's lives have been turned upside down. Allison starts to have dreams about a boy who was kidnapped from a toy store, but is unable to turn to Devalos or Scanlon for help. She decides to call the company hired by the missing boy's family and makes an unusual deal with the company's investigator, Cynthia Keener.

When Allison becomes a lawyer and Joe starts a new job, the Dubois family is forever changed on the series finale of Medium.