Someone is killing a number of homeless people and draining their blood. Then a museum guard is killed the same way and a special artifact is stolen, a Mayan cup that Nick believes can help him become mortal again. Nick suspects that his old mentor Lacroix is in town and behind the murders. Forced into a partnership with the unbearable Detective Schanke, Nick has to face both Lacroix and the Homeless Killer while trying to protect his friends.

Someone is killing a number of homeless people and draining their blood. Then a museum guard is killed the same way and a special artifact is stolen, a Mayan cup that Nick believes can help him become mortal again. Nick suspects that his old mentor Lacroix is in town and behind the murders. Forced into a partnership with the unbearable Detective Schanke, Nick has to face both Lacroix and the Homeless Killer while trying to protect his friends.

A series of bizarre murders lead Nick and Schanke to believe that somebody is hunting the city's most dangerous criminals for sport. When they go undercover to catch the killer, Schanke is taken hostage and it is up to Nick to save him before the hunter makes Nick her ultimate trophy.

The two day search for Natalie Lambert's young niece ends when the missing girl's body is discovered in the woods. After Nick Knight rescues the alleged killer from an angry mob of vigilantes, a blood test and line-up fail to provide enough evidence to hold him. Removed from the case because of her ties to the victim, Natalie questions the results of the lab work. When the suspect suddenly dies, Natalie performs her own lab test and uncovers another murder.

Nick discovers an ancient, terrifying evil is behind a series of grizzly murders plaguing the city, and he may not be able to stop it. He is unknowingly paired with Chief Inspector Liam O'Neal of Dublin C.I.D., a vampire hunter with a dark secret, who has tracked the murdering creature's bloody trail half way around the world. Wary of O'Neal, Nick begins an investigation of his own, learning the Chief Inspector's true identity, as well as that of the killer -- Jack the Ripper -- a vampire created by LaCroix. Nick had a chance to destroy the Ripper a century ago, but turned his back, unleashing a century of carnage around the world. He must now put aside his guilt and finish the job, but in doing so, O'Neal may finish him.

A crazed killer using a flame-thrower to torch his victims sends Nick and Schanke on an underground pursuit. In the confined quarters of the underground sewer system, it's anybody's guess who will find who first. While Nick faces his fear of fire, Natalie discovers she has her own fears to deal with.

A man's death seems directly related to a court battle over Native American land. But when during the invesitigation Nick comes into contact with a spiritual healer who sees the darkness inside him, the case seems suddenly unimportant. As Nick focuses on the possibilities of this spirtual realm, strange things begin to happen. Things seem to go from bad to worse when the murders escalate, and Nick is afraid he may somehow be responsible.