While almost everyone on the island is knocked out in the blast, Zoro slashes Kuma with Shishi Sonson, but sees that it is ineffective, as Kuma is a Pacifista, a cyborg whose body is harder than steel. Seeing that he can no longer fight, Zoro offers his life to save Luffy, saying that he cannot hope to become the world's best swordsman if he cannot protect his captain. Sanji attempts to take Zoro's place, but Zoro knocks him out. As part of his agreement with Kuma, Zoro takes in all of Luffy's pain and fatigue, which Kuma says would kill him if he suffered it on top of his already severe wounds. Zoro takes in the pain, and Kuma leaves, remarking on how Luffy has a loyal crew. Luffy regains consciousness, surprisingly energetic, while Zoro emerges from his sacrifice near death.

Luffy and Doflamingo duke it out while the Birdcage tightens its grip on Dressrosa! Zoro sets off with a plan to stop it from slicing apart the country, while Luffy's Fourth Gear proves quite potent against Doflamingo!

Luffy and Katakuri are locked in a duel to end all duels! Their powers ensure that each blow could be the last! Luffy must rely on his training, let all his thoughts out, and keep pushing on! Meanwhile, Sanji is about to land at Cacao Island!

Orochi plots to take the shogunate with Higurashi's assistance. As Oden continues his journey with the Whitebeard Pirates, he finally encounters the Roger Pirates. A clash between Edward Newgate and Gol D. Roger ensues.

Luffy, Law, and Kid join the Akazaya samurai and begin to fight Kaido’s army. The three rivals from the Worst Generation compete with each other as they attack the enemy fleet with their ultimate skills. When it seems like they gain upper hand in the battle, another strong enemy appears to help Kaido’s army.

Luffy and the rest of the Straw Hat crew are excited to see Jimbei again and welcome him as a new member. Meanwhile, Law and the Akazaya members strategize on how to enter Onigashima and attack Kaido. As the Straw Hats approach the giant torii gate in front of Onigashima, they are attacked out of the blue.

Evading Ulti and Page One, strong members of the Tobi Roppo, Luffy tries to find out what Kaido’s son Yamato’s motive is. However, the two get in a fight. Taking Luffy’s punishing attacks, Yamato remembers someone he fought against in the past.

As the Minks struggle with a poor hand against the Gifters, Kin’emon tries to assist them, but Dogstorm and Cat Viper stop him and start fighting for the other Minks! Meanwhile, Luffy and Zoro try to get to the rooftop to help Kin’emon and the others, but Queen and King get in their way.

Zoro and Drake continue to chase Apoo to get the antibody against Ice Oni, while Chopper is trying to figure out how to fight the virus. In the castle, Luffy, Jimbei, and Sanji are climbing up the stairs to reach the rooftop where the Akazaya members’ tough battle against Kaido rages on.

Yamato tells Momonosuke and Shinobu that he once confronted a man, who came to Onigashima looking to get Kaido’s head. His name was Ace. The two of them engaged in a fierce battle that eventually turned into an important friendship.

Sanji is forced to run with Zoro on his shoulder. Meanwhile, Nami bravely stands up against Ulti and Big Mom. On the rooftop, the intense battle between Luffy and Kaido finally comes to an end.

Who’s-Who expresses fierce resentment toward Luffy and Jimbei fights back out of his loyalty to Luffy. As Who’s-Who asks Jimbei a question, he tramples on the dignity of the Fish-Men and that sparks Jimbei’s outrage.

Killer is shocked to find out who Hawkins’ straw doll he slashed represents. Meanwhile, Sanji who is in a hard battle against Queen and King sees enemy brutes going after the injured Zoro, and no one else is there to save him.

Zoro still can’t gain control of Enma which keeps extracting his Haki. Backed into a corner by the formidable King, Zoro remembers the encounter with an old man in his hometown when he was a child.

Queen’s formidable attacks remind Sanji of his family. Annoyed by Queen’s provocations, Sanji remembers a young woman mysteriously getting hurt in front of him and realizes what happened at that time, which lights a fire within him.

Kaido remembers how he was treated unfairly in the past and how he believes the world should be. While his friends struggle to survive on Onigashima, Luffy is asked by Kaido to picture his ideal world as he throws a destructive punch.