A mysterious country, a rampaging slasher, ancient samurai rituals of seppuku - and Zoro in the crosshairs! When a street assault occurs, all signs point to Zoro! Meanwhile, Luffy finally arrives at the Land of Wano but all his friends are nowhere to be found.

Luffy and Komachiyo leave Hitetsu to take Tama to a doctor. At a wasteland, Zoro saves a woman from two Beasts Pirates. After arriving at the wasteland, Luffy reunites with Zoro. However, they are soon confronted by Hawkins.

As Komachiyo flees with Luffy, Zoro, and the ill Tama, Hawkins pursues them with the straw entity. Zoro defends against the straw entity's attacks and eventually defeats it. After the group escapes from Hawkins, Tsuru, who had been hiding inside Komachiyo's tail, reveals herself and invites the group to her teahouse in Okobore Town, where she can help Tama.

After defeating Holdem, Luffy grabs Tama and flees the scene. During the escape, they encounter Speed and Tama tames her. They then catch up to Zoro, Kiku, and Komachiyo as the latter three were fleeing with the stolen food cart. Meanwhile, Law fights Hawkins but their battle is interrupted when the food cart passes by them. After jumping on the food cart, Law reprimands Zoro for his group's actions.

Wano's most popular courtesan heads to the palace, but a revenge plot threatens the proceedings.

After claiming responsibility for Kin'emon's secret message, saying it was a prank, and casting doubt in the Rasetsu prison guards, Yasuie meets a brutal end as Orochi and his men shoot him to death. As the Ebisu Town citizens "laugh" over Yasuie's death, Hiyori reveals to Zoro that they were affected by the fruits known as SMILE.

Big Mom subdues Queen when the latter tries to fight her. During that scuffle, Kid and Killer are saved from drowning. Big Mom does not find any oshiruko, and when Luffy blurts out that he ate it, she attacks him out of rage. Luffy and Hyogoro are forced out of the ring, but Luffy manages to remove the collars before they are killed. Afterwards, Hyogoro decides to test Luffy by having him defend against Big Mom's attack.

After Udon is conquered, Chopper tends to Luffy and works to develop a cure for his condition. Luffy asks Kid to join the fight against Kaido, but Kid rejects his offer and leaves Udon with Killer. After finding out that Luffy is a pirate, the prisoners distrust him, but Momonosuke speaks to them and convinces them to join the cause to liberate Wano Country. Elsewhere, Ashura Doji reveals to Kin'emon and Inuarashi that he had comrades who were too impatient to wait for the Kozuki Family to return and died when they tried to fight Kaido. Afterwards, Ashura comes around and decides to rejoin Kin'emon.

At the secret place where Kawamatsu stored weapons, Zoro agrees to return Shusui in exchange for Enma. At the Flower Capital, Law subdues Hawkins and escapes prison with the help from an unknown individual. As the day of the Fire Festival draws closer, the Ninja-Pirate-Mink-Samurai Alliance continues with their preparations for the raid on Onigashima. Apoo returns to Wano with a group of gigantic beings known as the Numbers. At Onigashima, Kaido and Big Mom decide to put aside their feud and form an alliance to conquer the world.

It is revealed that Orochi had the Beasts Pirates bombed the Thousand Sunny and destroyed some bridges to cut off routes to Tokage Port. At the port, the Nine Red Scabbards prepare to continue with the raid on their own. A flashback to many years ago begins.

Orochi plots to take the shogunate with Higurashi's assistance. As Oden continues his journey with the Whitebeard Pirates, he finally encounters the Roger Pirates. A clash between Edward Newgate and Gol D. Roger ensues.

Enraged by Orochi’s tyrannical acts, Oden raids his castle in the Flower Capital and points his sword at Orochi. However, hours later, people who were waiting for Oden to come out after defeating Orochi see the unexpected. Meanwhile, the King of the Pirates Roger’s execution and last words are printed in newspapers and spread across the world.

As Kin’emon and the others run to Oden Castle to save Oden’s family, the castle is set on fire and Kaido attacks Toki and her children. Leaving Momonosuke to Kin’emon and Hiyori to Kawamatsu, Toki appears in front of the desperate people of the Land of Wano and gives a prophecy.

Luffy, Law, and Kid join the Akazaya samurai and begin to fight Kaido’s army. The three rivals from the Worst Generation compete with each other as they attack the enemy fleet with their ultimate skills. When it seems like they gain upper hand in the battle, another strong enemy appears to help Kaido’s army.

Eustass Kid and his clan start heading for Kaido's castle head on waving Luffy off. Luffy and Zoro go after them to stop them from causing trouble, but they happen to step into Kaido’s banquet. Meanwhile, Kanjuro loses his way to Kaido in underground passages with Momonosuke who he kidnapped in tow.

The furious Big Mom chases Brachio Tank driven by Chopper and Usopp, but they bravely fight back! Meanwhile, Kanjuro takes the battered and bruised Momonosuke to Kaido and Orochi, then breaks the news to them about Oden’s retainers who were thought to be dead.

While Kaido begins the New Onigashima Project, Marco appears in front of Chopper and the others, who are struggling with Ice Oni. The members of the Tobi Roppo continue to give the Straw Hats a hard time while their former member helps Zoro.

Luffy, Law, Kid, Zoro, and Killer keep landing hard blows against Kaido in tandem despite the arguing. However, when Big Mom steps in and unleashes powerful lightning strikes, the tide turns for all except one of the rookies.

Chopper works hard to make the cure for Ice Oni, even though he is turning into one himself. Meanwhile, the infected Boss Hyogoro the Flower regains his youth and fights fiercely to protect Chopper and the others.

Kin’emon and the Akazaya members are rushing to help Momonosuke and everyone else while Yamato leaves Momonosuke and Shinobu in a hide-out to lure away their enemies. At the same time, Ulti tries to avenge her brother against Big Mom.

To cut ties with Kaido, Yamato unleashes his true power. Meanwhile, Queen repeatedly attacks Sanji with his power as a cyborg, and Sasaki in his Man-Beast Form launches tricky attacks on Franky and drives him into a corner.

Zoro gets back on his feet and along with Sanji, confronts King and Queen, the Lead Performers of the Animal Kingdom Pirates. Watching Zoro fight, Hyogoro and Kawamatsu remember someone from way back.

Momonosuke faces Kaido once again trembling in fear. However, with Luffy’s encouragement, he bravely steps up and shows his dragon fangs remembering what he had to go through because of Kaido.

Killer tries to figure out how to fight against Hawkins whose power enables him to transfer damage against him to Kid. Kid is dying not knowing where his damage is coming from. Killer takes a chance with Kid’s life on the line.

Zoro is facing a hard fight against King who seems invincible. Even one of Zoro’s deadliest attacks doesn’t leave a scratch on him. On top of that, one of Zoro’s swords goes out of control and gets in his way.