Leo discovers three teen super-humans Adam, Bree and Chase, living in a secret underground lab in the high-tech home he shares with his inventor stepdad, Donald Davenport, his mom, Tasha, and Eddy, the "smart house" computer. Leo takes the trio to school, but when they are unable to contain their bionic abilities on campus, Davenport sends them away to a remote secret lab.

When Leo needs help asking a girl to the school dance, Adam and Chase step in to help, but the plan backfires when she falls for the wrong brother. The boys decide to settle their differences on the dance floor and each show off their best moves. Meanwhile, Bree gets to know her crush, but he gets to know her glitche

The Lab Rats get their first mission to stop Davenport's hi-tech super fast train from speeding out of control.

When Davenport's prized invention, a super strength and laser empowered exoskeleton suit, malfunctions, after Chase reverses its controls, to get back at Leo for stealing his presenting job. However, it ends up unleashing destructive power on the household, making Leo's grandma even more suspicious of the family.

When Adam, Bree and Chase forget to invite Leo to his surprise birthday party, they must make it up to him, so they take Leo into the ultra-cool virtual mission simulator and show him what it's like to be bionic.

Leo borrows Davenport's helicopter to take Janelle on a daring date. Bree gets her own room and Adam and Chase are excited to have a room to themselves. But things get out of hand and Chase divides the room up.

Leo is left alone to care for the Lab Rats, but things quickly go wrong when he plays with a new gadget that glitches Adam, Bree, and Chase.

Adam, Bree and Chase learn about chores and earn allowance for the first time. To raise more money, they host a yard sale and accidentally sell an antique jewelry box that Davenport was restoring for Tasha.

Tasha takes the entire family on a nice 'tech free' beach weekend in the RV, but when Davenport discovers a solar flare headed in the Earth's direction, he secretly enlists the help of the Lab Rats.

When Leo accidentally messes up Eddy, an evil demon Teddy replaces him.

Adam, Bree, and Chase are caught on Principal Perry's surveillance camera using bionics.

Chase accidentally discovers that he has a hidden ability - telekinesis.

Adam, Bree, and Chase sneak out to meet Marcus in Davenport’s new self-driving sports car. When Leo tries to stop them, his nemesis Marcus traps him inside the car and programs it to take him on a wild, high-speed ride bound for the bottom of the Pacific Ocean.

The lab rats go on strike and express their desire to do normal teenage stuff, so Davenport recruits Leo as a "scab" rat for an upcoming demonstration.

One of Davenports inventions accidentally sucks Leo into an opposite parallel universe where Leo's the one with Bionics, Principal Perry is nice, Adam is a nerd, Chase is a Jock, and Bree is popular.

Leo follows Marcus to his secret lair (an abandoned train station) to gather evidence that proves he's bionic but ends up captured by Marcus and told that there bionics are just some dumb tricks. Meanwhile, the Lab Rats scramble to bring Tasha back before Davenport finds out that they accidentally teleported her to parts unknown.

Adam gets a truck. Leo tries to get her mother out of being PTA teacher.

Adam, Bree and Chase use Mr Davenport's new invention to erase moments that could land them in trouble. While, Leo causes chaos when he uses the gadget to accidentally wipe 24 years of Mr Davenport's memory, resetting him to his 15 year old self.

When Mr. Davenport invents a new freeze ray gadget, he sends the Lab Rats on a mission to Antartica to collect ice-type fuel for his invention. But when a 'category 5' storm hits Antartica, he calls the mission off. Ignoring Davenport's orders, Chase goes anyways, alone and gets trapped in an avalanche after it collapsed on him. When he tries to find a way out, he runs into Douglas along the way. Meanwhile, Leo tries to impress Janelle, but accidentally freezed her using Davenport's freeze ray gadget.

Bree is tired of being the target of the boys' pranks.

The Lab Rats go on a rescue mission to save Dr. Evans and travel to Davenport's secret facility in the frozen tundra.

The Lab Rats are forced to expose their bionic secret in order to save Principal Perry.

Leo and Donald escape the elevator. Principal Perry lets them stay at the school temporarily in order to get her money from Donald quicker. The Lab Rats stow away on a cargo ship to hide from the FBI and must choose to either keep quiet or help stop a submarine that will crash into the ship and risk being caught. The Lab Rats decide to stop the submarine, with Chase activating his GPS, revealing the Lab Rats' location. Douglas ends up capturing them, disguised as Donald. Douglas reveals that his new bionic partner is a billionaire named Victor Krane, who wants to destroy the Lab Rats permanently. When Donald calls the Lab Rats and tells them that Principal Perry kept their secret, they return home, only for them to get crazy as a result of the Triton App and attack the family, Leo manages to disable Chase's Triton App when he talks to him and Chase manages to disable Adam and Bree's apps. The Lab Rats and the family later see the demolition that happened to the lab and are upset.

Leo and Donald escape the elevator. Principal Perry lets them stay at the school temporarily in order to get her money from Donald quicker. The Lab Rats stow away on a cargo ship to hide from the FBI and must choose to either keep quiet or help stop a submarine that will crash into the ship and risk being caught. The Lab Rats decide to stop the submarine, with Chase activating his GPS, revealing the Lab Rats' location. Douglas ends up capturing them, disguised as Donald. Douglas reveals that his new bionic partner is a billionaire named Victor Krane, who wants to destroy the Lab Rats permanently. When Donald calls the Lab Rats and tells them that Principal Perry kept their secret, they return home, only for them to get crazy as a result of the Triton App and attack the family, Leo manages to disable Chase's Triton App when he talks to him and Chase manages to disable Adam and Bree's apps. The Lab Rats and the family later see the demolition that happened to the lab and are upset.

Since the lab is destroyed, the Lab Rats go without their capsules. This causes glitches in their bionics. In order to prevent this, Donald pulls off a huge stunt in a fiberglass jet wing he invented. Things go wrong when the jet wing runs out of fuel. Meanwhile, knowing the Lab Rats' bionic secret, Principal Perry uses Adam and Bree as her bionic servants for the day.

Bree gets a part-time job at a tech-support store with Caitlin, but gets out-shined by Chase while he is talking to the manager of Tech Town, Scott. Chase sees how she feels later and they agree to treat each other with respect. Meanwhile, while Tasha is away visiting Grandma Rose, Leo and Adam make a turbo zip-line instead of doing the chores that Tasha gave them, with Donald joining them later. When Tasha finds out about the zip-line, she makes the boys do the chores and she hangs out on the turbo zip-line instead, much to the dismay of Adam, Leo, and Donald.

Leo invents his first high-end technological creation, a pair of attack orbs meant to protect the family, but when they can't differentiate between friend and enemy, they create more bad than good. Meanwhile, Chase steals Donald’s Eddy technology to make a Cheddy application to win a Tech Town employee contest and beat Scott, but things go wrong when the technology doesn't work as expected. Leo and Tasha go to see Janelle's play which Adam is starring in, but when Trent steals Leo's ticket, Leo and Trent ruin her play, much to Adam and Janelle's dismay.

Donald shows a new motorcycle to the Lab Rats when they get a video message from Douglas that Krane has lost it and implanted himself with more bionic abilities, abilities even he doesn't know about. The Lab Rats instead believe this to be a trap, leading Donald to activate a new security system that only he can bypass. While Leo is at Mission Creek High School, Douglas arrives and tries to appeal to Leo by reminding him that he knew about Douglas and Marcus before the rest of them. Douglas then shows Leo video footage of Krane implanting himself with bionics and asks him to call his brother to prove his honesty. Back at the lab, a transmission comes in and shows Leo and Tasha captured. While Donald thinks it's Douglas, Krane reveals himself on-screen as the captor and demands that the Lab Rats arrive in 10 minutes. While the Lab Rats want to rescue them, Donald heads out alone with an extremely powerful thermal blaster. Donald arrives at Krane's lair, only for Krane to siphon the power from the blaster, rendering it useless and quickly beating Donald with super strength and molecularkinesis. During the battle, Leo and Tasha are trapped in an exothermic energy field to fry them. Afterward, Krane geo-leaps to the lab, allowing Donald to use the thermal blaster to suck in the heat to set Leo and Tasha free. As Chase works to deactivate the security system, Krane arrives and easily beats the Lab Rats with his more advanced bionics. Before Krane can finish them off, Douglas arrives and blasts Krane with a laser blaster. Although he saves the Lab Rats, Krane quickly recovers and knocks him down with another force wave. As he once again prepares to attack, Chase repels his blast back at him with a force-field, defeating him for good. Douglas plans to capture the unconscious Krane, but Donald arrives and blames the entire mess on him. Unfortunately, Krane geo-leaps out of the house and Donald demands that Douglas leaves.

Bree is accepted for a semester abroad program in Australia, but when Donald learns about it, he refuses to let her go. When Donald again refuses to let her go to a concert with her friends in favor of bionic chip maintenance, she decides she's had enough and smashes her bionic chip, much to Adam, Chase, and Donald's horror. At first, Bree relishes her new freedom and even begins bragging to a disgruntled Leo. During a mission, Bree feels helpless as Adam and Chase are gone for hours. Chase reveals that they barely made it out alive and because Bree is no longer bionic, the mission took twice as long. Bree realizes she was selfish and apologizes to Adam and Chase. She's ready to become bionic again, but Donald sadly tells her that since Douglas built the chips, he isn't sure if Bree will ever be bionic again. Meanwhile, Tasha is sick, so Leo decides to use his new pill invention on her to see if her diagnosis will reveal the problem, but when he takes some of the software from Eddy, Eddy is stuck in Tasha's body. Eddy spends the day dressing her horribly and getting her kicked out of every spot in town. Donald finally uses his nasal vacuum on Eddy and the pill is extracted. However, Eddy reveals he did a news report as Tasha, and much to her shock, he made her look like a complete buffoon.

When the Lab Rats are on a mission, it is revealed that a girl was secretly recording them behind a bush. The next day, the Lab Rats go to school and everyone is looking at a viral video called The World's First Bionic Humans. They go back home to tell Donald, but he says he already knows. Meanwhile, Chase is confused that he didn't notice the girl who filmed them behind the bush, even though he thermal scanned the whole place. He then looks at a chip log and finds out that the girl was in the exact spot he scanned. Chase then goes to tell Donald, but a swarm of government agents surrounds them. Leo and Douglas are still in the lab, but they use a trap door to escape and go to school to stay safe. It is then revealed that the mission the Lab Rats were on was a setup. Krane then shows up with the girl who filmed the Lab Rats, whose name is revealed to be S-1. It is also revealed that she is bionic. Krane electrocutes Principal Perry and Douglas while S-1 crushes Leo's arm. Later, Douglas and Principal Perry help Leo to get his arm fixed and take him to the hospital. Tasha later shows up, only to realize that Leo is gone. While the Lab Rats are saying their goodbyes, Special Agent Graham tells them it's time to leave, but Adam refuses. Agent Graham orders his agents to take them down, but Adam uses his wave blast ability to knock them down. When they run to the hospital, Principal Perry tells them Krane is responsible for exposing their bionics. Meanwhile, Leo is in Douglas and Krane's old warehouse and Douglas tells him to take his bandage off and pretend to throw a ball. He then realizes that Douglas upgraded his right arm with bionics. Krane then shows up and knocks down Leo and Douglas. The Lab Rats then show up with Donald, as Krane uses a powerful bionic ability that knocks out Leo, Donald, and the Lab Rats. Krane then paralyzes Donald with his choking ability. Bree battles S-1 while Adam and Chase battle Krane, but he easily takes them down with his newly upgraded Triton App that he uses on S-1. Leo then uses his bionic arm to take down Krane. As Agent Graham arrives, Douglas reveals that Krane and S-1 are the bionic villains. Agent Graham is then saved by Bree as Krane tries to attack him and he takes Krane and S-1 into custody and locks them in a prison with a bionic signal interrupter, preventing them from using their bionics to get out. Later, the Lab Rats are at a press conference and reveal that they are bionic superhumans. While watching it, Principal Perry makes new friends with the Lab Rats. In the end, Agent Graham tells Donald he's now in charge of the Lab Rats. It is also revealed that Krane has an army of bionic soldiers, which he will use to destroy the Lab Rats.

When the Lab Rats are on a mission, it is revealed that a girl was secretly recording them behind a bush. The next day, the Lab Rats go to school and everyone is looking at a viral video called The World's First Bionic Humans. They go back home to tell Donald, but he says he already knows. Meanwhile, Chase is confused that he didn't notice the girl who filmed them behind the bush, even though he thermal scanned the whole place. He then looks at a chip log and finds out that the girl was in the exact spot he scanned. Chase then goes to tell Donald, but a swarm of government agents surrounds them. Leo and Douglas are still in the lab, but they use a trap door to escape and go to school to stay safe. It is then revealed that the mission the Lab Rats were on was a setup. Krane then shows up with the girl who filmed the Lab Rats, whose name is revealed to be S-1. It is also revealed that she is bionic. Krane electrocutes Principal Perry and Douglas while S-1 crushes Leo's arm. Later, Douglas and Principal Perry help Leo to get his arm fixed and take him to the hospital. Tasha later shows up, only to realize that Leo is gone. While the Lab Rats are saying their goodbyes, Special Agent Graham tells them it's time to leave, but Adam refuses. Agent Graham orders his agents to take them down, but Adam uses his wave blast ability to knock them down. When they run to the hospital, Principal Perry tells them Krane is responsible for exposing their bionics. Meanwhile, Leo is in Douglas and Krane's old warehouse and Douglas tells him to take his bandage off and pretend to throw a ball. He then realizes that Douglas upgraded his right arm with bionics. Krane then shows up and knocks down Leo and Douglas. The Lab Rats then show up with Donald, as Krane uses a powerful bionic ability that knocks out Leo, Donald, and the Lab Rats. Krane then paralyzes Donald with his choking ability. Bree battles S-1 while Adam and Chase battle Krane, but he easily takes them down with his newly upgraded Triton App that he uses on S-1. Leo then uses his bionic arm to take down Krane. As Agent Graham arrives, Douglas reveals that Krane and S-1 are the bionic villains. Agent Graham is then saved by Bree as Krane tries to attack him and he takes Krane and S-1 into custody and locks them in a prison with a bionic signal interrupter, preventing them from using their bionics to get out. Later, the Lab Rats are at a press conference and reveal that they are bionic superhumans. While watching it, Principal Perry makes new friends with the Lab Rats. In the end, Agent Graham tells Donald he's now in charge of the Lab Rats. It is also revealed that Krane has an army of bionic soldiers, which he will use to destroy the Lab Rats.

During Christmas, when the Lab Rats discover that their new action figures are being outsold by another toy, The Nerble, they attempt to improve their toys by adding special features. After adding them they decide that the toys are too dangerous for kids and put them in a box to be destroyed. Tasha is running a toy drive at the school and is collecting gifts. She finds the action figures and hands them out. When the Lab Rats find out, they rush to school and try to catch the action figures. After destroying the toy drive, they find a way to make it up to Tasha and the kids. Leo and Donald have a snowball fight in the house and Grandma Rose shows up just as Leo uses his bionic arm. Rose gets mad and calls Donald a bad father. Donald tries to makes it up to Rose by giving her a Bree action figure, but it promptly explodes.

Donald is in critical condition after the battle with Krane and his soldiers; Leo visits him in the hospital and in an attempt to save him, he risks his life to perform a dangerous bionic process, accelerating his aging process, thus turning him into an old man. Meanwhile, after being deactivated from the Triton App, Krane’s former bionic soldiers have nowhere to go and follow Adam home. The Lab Rats try to protect them because they aren't evil anymore. However, the president doesn't get this and tries to have them arrested, but changes his mind when the soldiers use their powers to heal and save Leo who almost died of old age. Right when they are going to be taken into custody, a newly healed Donald strikes up a deal with the president to build an academy for the soldiers.

When Leo is injured during a mission, Tasha rushes to the academy to take care of him. After finding out what happens on missions, she bans Leo from joining any more missions, but he disobeys her and goes on a mission with the rest of the team. When Tasha finds out, she kicks Leo off the team and tells him that he is moving back to Mission Creek.

Tasha arrives on the Bionic Island informing everyone that she has tickets to a big football game of the Pioneers (mascot of a college that she went to) vs Vikings (mascot of a college that Perry went to) and Perry arrives stating that she has been trying to score tickets for weeks but it was sold out. When she asks Tasha if she has any tickets, Tasha lies saying that she hasn't. When they are about to enter the game, Perry eventually finds out the truth, she becomes furious and destroys the tickets which causes Leo, Donald, and Tasha to try to get new tickets competing against her in The Ultimate Tailgate Challenge, hosted by NFL former linebacker Willie McGinest. Meanwhile, Bree attempts to achieve her college experience by fitting in with a couple of college students (who are football fans) and attempting to use her bionics to impress them.

In the middle of a massive heat wave, the whole family is going to space to see Donald's space colony, called "Davenportia". Adam annoys Chase while Chase tries to give his safety instructions and accidentally blasts them into space. After leaving the solar system, they initiate hyper-speed and land on the planet Lithios. In the dome, it's discovered that Perry sneaked her way in with the rest of the colonists.

Donald and Douglas reveal that they have built an upgrade for all the students bionics, except for Leo's. But the upgrade doesn't work on Adam, Bree, and Chase because their systems are older. Adam, Bree, and Chase are therefore left at their level, while all the students are much more powerful. Meanwhile, Daniel is brought to the Academy because he had been using his bionics in the outside world. Douglas decides to enroll Daniel at the Academy, and he makes Leo his mentor. Leo steadily tries to teach Daniel, but Daniel proves to be unteachable, so Leo gives him the upgrade as well. The students steadily start to vanish, including Daniel. Giselle Vickers, Douglas' old girlfriend, is revealed to have captured them. Daniel sends a video message to the Island, requesting help.

Giselle reveals she dug up Marcus from Douglas' old lair and rebuilt him, piece-by-piece. Marcus wants revenge on Douglas for leaving him to die. Everyone rushes Giselle and Marcus, but Marcus knocks everyone unconscious. Donald and Douglas are tied together in chairs, while Adam, Bree, Chase, and Leo are put in the chamber with the students, while Daniel is pulled out.