Alex and Charlie are caught in the middle of a shooting on their way to their first shift back at Hope Zion. In the midst of the commotion, Alex treats a bullied teenager and deals with her own emotions about everything that’s happened in the past year. Meanwhile, Charlie is caught off guard when he realizes that he’s still able to see the spirits of deceased patients. As well, new Chief of Surgery Joel works alongside Charlie’s ex-wife Dawn to perform an intense surgery.

Alex must learn to stick up for herself and not be intimidated by Dawn (Charlie’s ex-wife) in order to work alongside her and perform a minimally invasive heart procedure to save a patient’s life. Meanwhile, Joel unlocks a mystery to a young girl’s disease, while getting some advice from Charlie, who is trying to figure out how to help his comatose patient come back from being a spirit. It’s a week of defying the odds at Hope Zion Hospital.

Alex is trying to get her life back to normal with Charlie and at Hope Zion Hosital – but with Charlie’s head in the clouds and the pressure to find her medical niche – she’s struggling. Inspiration comes in the form of an immigrant doctor who needs Alex to save his wife’s life, and in return, helps her find her calling.

The doctors at Hope Zion Hospital are forced to deal with people from their past as Alex, Charlie and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path. Meanwhile, Zach is tested when the last person he wants to treat comes into his E.R. and a Season 1 patient returns with some difficult insight for Charlie and Alex.

Alex must become the unlikely advocate for a violent young prisoner brought in to Hope Zion Hospital, while Joel connects with a disfigured refugee and tries to convince Dr. Dana Kinney to come back to operate on him. Meanwhile, a spirit who is familiar to many Hope Zion doctors shows up in the morgue when Charlie is about to do routine procedure.

After a young, healthy and hunky fireman dies suddenly at Hope Zion Hospital, Alex must take the stand at Hope Zion’s Morbidity and Mortality (M&M) Rounds to find out what went wrong and who is to blame. Meanwhile, Charlie deals with a nervous aspiring Nun, and Joel has to decide if he can be the man that comes through for Sonja.

When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.

When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they’re forced to use only what’s around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.

When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane – and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who’s been admitted to Hope Zion Hospital.

When Alex’s brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient’s gorgeous OB/GYN.

Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy’s life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex’s dead brother Luke.

Alex is surprised twice in one night – first when she realizes she's been tricked into a blind double date, and again when she has to rush her mystery man to the ER.

Alex performs surgery on one of the hospital's own doctors; a routine checkup turns deadly; a medical conspiracy extends far beyond Hope Zion.

Alex witnesses an accident involving a John Doe; Charlie and Gavin have a spiritual therapy session.

A couple is attacked by a bear, but Alex and Charlie think there's more to the story; a Buddhist tries to teach Joel a lesson.

Alex races to find an organ replacement; Joel helps a couple; Charlie is pushed to his breaking point.

An elderly patient believes she's living in a different time; Charlie and Joel get competitive; Maggie is forced to take the reins during a surgery.

Alex is diagnosed with an irregular heartbeat but must care for the Great Randall; Charlie deals with the aftermath of the fight; one of the staff is attacked.

Alex was stabbed in the chest and Charlie sees her as ghost. Alex realizes she saw her father hang himself. Joel has issues with himself about Alex. Maggie end hers and Gavin's relationship. Alex end up in coma and remains ghost.

Alex's spirit shares an emotional journey with Charlie in the spirit world. Joel treats a drug addicts necrotic leg and strikes up a unlikely close bond to the patient. Dr. Sydney Katz begins her new job throwing Maggie off her game.

Alex is awake but still not back to her old self, and Dawn has given strict orders for her recovery plan. Meanwhile, Charlie and Joel square‐off over differing treatment options when two fused-together burn victims are brought into the ER, and Maggie finds herself in a whirlwind of emotions triggered from the fallout of her miscarriage.

Alex returns to work for the first time since her stabbing. She is introduced to her buddy colleague, as she returns. Joel ends up involved in a deadly situation at a local street clinic. Gavin shares a euphoric experience, with someone unlikely.

A mother and son are brought to the hospital after been involved in a car crash. Alex and Joel discover that the mother needs a transplant, and the son is adamant that he be involved in the operation. Rian and Maggie get caught up in a hazardous situation.

Alex, Maggie and Joel face a mystery; Charlie meets a patient with an usual link; an unexpected visitor has Zach questioning his abilities as a dad

Shahir and Alex attempt a radical surgery on an Alzheimer's patient; Tom discovers his mentor is keeping a secret; Charlie is torn between Dawn's wishes and the final requests of a dead con-man.

Alex and Charlie perform a double surgery on a teenage girl; Joel works at the clinic; Maggie must pull through when she is reunited with the Zarb family.

Alex and Joel are challenged with a marathon surgery. Charlie has a day off that's full of surprises. Dana, Zach and James are tested.

Celebrated neurosurgeon Thor MacLeod gives Alex an offer; Charlie deals with a fatigued spirit; Joel ends up in a fight at the clinic.

Charlie tries to treat two female MMA fighters; a fight between Dana and Molly ends up in the hospital; Dawn must save a woman's heart.

Two patients need the same heart; a patient has never-before-seen orthopaedic hardware; Dr. Maggie Lin feels the pressure of the upcoming boards.

Alex encounters a trapped teenager during a hike in the woods; a woman refuses to see anyone but Joel; an exotic dancer comes to the ER.

Alex and Maggie perform an intricate procedure; Joel thinks his dad is hiding something; Charlie suspects foul-play when he sees a boy and his grandmother.

Alex asks for help in diagnosing a teacher with a mysterious illness; Charlie must explain his actions; Dawn must make a big decision.

Alex and Charlie try to save the life of a man on the run; a spirit won't leave Alex alone; Maggie and Zach try to help a couple; Joel and Shahir help a bride walk down the aisle.

Alex and Dana try to save a single mother's life; a hockey player's mobility is at stake; Charlie gets advice on winning back Alex; Sydney come clean

At an off-site army base, Joel and Zach get in a precarious situation; a hypothermia victim fights for the life; Alex, Maggie and Rian write their Surgical Boards.

On her first day back from maternity leave, Dr. Alex Reid has her hands full when a new mother comes in following a car accident.

Dr. Alex Reid puts her reputation on the line when she questions a senior surgeon’s methods.

Alex struggles with being a mom, a surgeon and now mentoring a junior resident.

The man responsible for Alex's brother's drug problem is admitted to the hospital.

A young motocross rider is diagnosed with Leukemia, forcing Dr. Alex Reid to navigate family secrets in order to put her young patient on the road to recovery.

Alex must decide whether or not to use the info Charlie got from a patient's spirit.

Alex tries to convince Shahir to use an aggressive treatment on a brain tumor patient.

When a trapeze artists dies, a line of patients in need of his organs cause complications.

Casualties of a bomb at a local charity run arrive at Hope Zion Hospital.

Alex discovers that she unknowingly helped the bomber at the expense of a friend.

During an ice storm on Christmas Eve, Alex and Dawn fight to keep a woman alive long enough for her family to say goodbye.

Faced with a chef who refuses treatment, Alex is forced to confront how she feels about Dana's methods.

Kristine shows up at the hospital with baby Luke's blanket.

Alex and Jeremy try to solve a child's mystery illness; Charlie treats an actor; Maggie reaps the rewards of compassionate medicine.

Charlie decides to go a day without using his special abilities; Alex organizes a trip to Dana's cabin; Zach takes control of a life and death situation involving Dawn's college roommate.

Alex and Cassie try to free a young woman from her abusive partner; a patient's pacemaker malfunctions.

Kristine suffers a stroke, which impacts her memory; Alex and Charlie team up to bring her peace.

Alex and Shahir struggle to save Charlie's life.

While searching for Charlie, Alex finds a caterer who was caught in the crossfire. Grace's mother asks for a priest. Dana consults with Cassie about a male stripper.

Alex and Charlie are confused about their relationship. Alex and Maggie disagree about a car crash survivor. Dana is forced to treat an injured motorcyclist. Zach bothers Maggie about dating.

Alex makes a promise to a young girl on her birthday. Maggie organizes a surprise party for Alex. Cassie is forced to confront her fear of infectious diseases.

Charlie tries to save the arm of a man thrown from a horse. Alex joins Manny off-site to help a runaway. A rival from Dev's past arrives at Hope Zion.

Alex tracks down the father of a patient who needs a liver transplant. The new CEO of Hope Zion is at odds with Dawn. Zach faces trials in the E.R.

Alex and Maggie ask Charlie for his opinion on a patient's treatment. Zach is persuaded by a patient while transitioning the ER to an urgent care facility.

Alex and Maggie deal with a tough lawyer after surgical complications with their cancer study patient. With the E.R. now an urgent care facility, Zach and his team aren't equipped to handle an accident victim.

Charlie and Manny treat a couple. Maggie evaluates the interns. Billy asks Maggie to be his mentor. Dawn tries to get her Chief of Surgery position back.

The doctors rally together to try to save an unknown man who was struck by a subway train. Randal delivers a warning about Charlie's gift. Dr. Sydney Katz returns to town.

Alex tries to distract herself from her grief. Charlie and Shahir try to track down Alex's brother. Alex treats a young girl with kidney failure. Maggie and Sydney treat a young woman with an STI.

While Charlie tries to save a young man's life, he is haunted by a mischievous spirit.

Alex and Maggie work together to deliver a baby. Charlie treats a magician.

Alex tries to help patient who hurt himself breaking into a house. A friend of Dr. Dev Sekara has been beaten by the police; a heart patient wishes to open an animal sanctuary.

Alex is challenged about the value of holistic medicine. Charlie's abilities are questioned. Two filmmakers go to Hope Zion Hospital.

The board questions the hospital staff about Charlie's behaviour. A patient convinces Alex to use new-age techniques. Shahir agrees to do an in-utero surgery.

Alex has to put her concerns for Charlie aside when a chance to perform a cancer surgery arises.

Alex and Charlie put their wedding plans aside. Zach takes a special interest in a case. A coma patient who wakes up with no memory.

Alex and Charlie rush to the scene of a mass casualty accident involving a bus full of teenagers.