In the premiere episode, the Chief of Surgery ends up in a coma, and his fiancée and fellow surgeons fight to save his life.

Alex Reid treats a young boy with mysterious symptoms while dealing with the arrival of Charlie's ex-wife. Elsewhere in the hospital, Joel Goran and Maggie Lin try to help a patient who refuses life-saving treatment on religious grounds.

With Charlie's life hanging in the balance, Alex and Dawn go head-to-head over who gets to be his legal decision maker - but are forced to put personal matters aside when they scrub into a heart transplant surgery together. Charlie, meanwhile, is in no mood to talk to the heart donor - a deceased prisoner.

In the Season 1 finale, Alex confronts game-changing questions following a monumental turn of events. Elsewhere, Joel scrambles to save a patient suffering from a rapidly spreading flesh-eating disease.

Alex and Charlie are caught in the middle of a shooting on their way to their first shift back at Hope Zion. In the midst of the commotion, Alex treats a bullied teenager and deals with her own emotions about everything that’s happened in the past year. Meanwhile, Charlie is caught off guard when he realizes that he’s still able to see the spirits of deceased patients. As well, new Chief of Surgery Joel works alongside Charlie’s ex-wife Dawn to perform an intense surgery.

When Alex’s brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient’s gorgeous OB/GYN.

Alex performs surgery on one of the hospital's own doctors; a routine checkup turns deadly; a medical conspiracy extends far beyond Hope Zion.

Alex witnesses an accident involving a John Doe; Charlie and Gavin have a spiritual therapy session.

Alex is diagnosed with an irregular heartbeat but must care for the Great Randall; Charlie deals with the aftermath of the fight; one of the staff is attacked.

Alex was stabbed in the chest and Charlie sees her as ghost. Alex realizes she saw her father hang himself. Joel has issues with himself about Alex. Maggie end hers and Gavin's relationship. Alex end up in coma and remains ghost.

At an off-site army base, Joel and Zach get in a precarious situation; a hypothermia victim fights for the life; Alex, Maggie and Rian write their Surgical Boards.

A young motocross rider is diagnosed with Leukemia, forcing Dr. Alex Reid to navigate family secrets in order to put her young patient on the road to recovery.