Danger 5 are fugitives in Metro City, wrongfully accused of kidnapping high school senior Holly De Palma. Hitler has infiltrated the police and leads the hunt for Danger 5 but little does he know that his own people are working against him: Joseph Mengele and his sinister accomplice Mr. Pedro are plotting a scheme, which involves the return of some scaly prehistoric bad-guys.

After being abducted by Mr. Pedro, Hitler is taken captive in the Vatican. A gang of surviving Nazi war criminals have formed a mutiny against Hitler and plan to hijack Catholicism in a bid for world domination. Pierre's faith is put to the test as he fights to save Christmas from the Nazis. Meanwhile Tucker retreats into a fantasy world, Ilsa encounters an old flame and McKenzie investigates Holly's newfound ability.