Iria, the young assistant bounty-hunter for her brother, Gren, is illegally out on her own job, only to have the bounty stolen from under her by a competitor, Fujikuro. Aware that she's unable to do anything legally, Iria has no choice but to let Fujikuro take her prize... Meanwhile, Gren has been given a choice assignment on behalf of the Tedan Tippedai Corporation: the rescue of the passengers and cargo of their starship, Karma, which has been hijacked by an unknown assailant. But there's a catch: the rescue must be carried out before the authorities arrive.

Severely injured during her last battle with Zeiram, Iria finds herself more reluctant to go after Zeiram -- at least not without some advantage she might be able to use. But Kei is not so cautious. Frustrated by Iria's apparent lack of initiative, Kei decides to go after Zeiram herself, only to be stopped by Fujikuro.

Meanwhile, the Mycean council's plan to build a huge transemmbler is met with forceful opposition by the Zeiramoid clones. Zeiram has resisted every know weapon on the planet, and the only plausible solution seems to be to transport it off world, and make it someone else's problem. But Iria knows the only solution is to stop Zeiram permenantly...