Selby, a double-agent for the U.S. within an enemy country's intelligence service, is suspected by his superior, Kellerman. The IMF must keep Selby in the clear and eliminate Kellerman. Selby complains when Marceau, a courier who knows about Selby's identity, is taken from him by Kellerman. Selby claims Kellerman is the double-agent. Rollin, as a government official, gives Kellerman 24 hours to break Marceau. Using his underling Brocke, Kellerman works with Rollin to trap Selby. Kellerman comes to believe that Agent Jim has kidnapped Brocke's girlfriend to force Brocke to give away Marceau's location to Selby. In reality, Stephanie is shown a fake split-screen of Jim conspiring with ""Kellerman"" (Rollin in disguise on tape!) to kill Brocke and eliminate Marceau. Brocke believes Stephanie and accuses Kellerman but she recants under pressure. Meanwhile, Marceau is wired to an explosive. When Stephanie recants the IMF break in using knockout gas and use liquid nitrogen to free Marceau. The

Alex Pierson, a rising Syndicate member, has recruited Dr. Burke, a psychopathic behavioral psychologist who has developed a way to program men into killers. Pierson lures in underworld criminals with an offer of plastic surgery and turns them over to Burke, who programs them to kill Pierson's targets three times then kill themselves. Barney infiltrates as a crook on the run but when he fails to dose himself with a counter-drug, he is converted into a psychotic killer as well. They lose contact with Barney - Jim plants evidence on Burke making him look like he's turning against Pierson and another IMF agent made up to look like Barney goes after but fails to kill Pierson before fake-killing himself. Pierson confronts Burke while Jim gets the info on Barney's location out of Burke's assistant, and Willy stops the tech expert from killing his target in the nick of time.

A government scientist, Paul Morse, plans to sell a biological weapon, TOD-5, to terrorist Alpha Group led by Dr. Flory. The IMF must get to Morse's contact, Gordon Holt, and get him to take them to Alpha HQ. When Holt gets to the small town where he is to get the weapon from Morse, he finds the town under quarantine and people dying - then he starts showing (IMF-faked) symptoms of the disease. He grabs Mimi, who is supposedly immune, and takes her with him to Alpha HQ and infects them to force them to come up with an antidote - the IMF trail him and arrest the whole operation.