Imry Rogosh is a mass murderer who kills to forment political upheaval. He is targeting Los Angeles, so the IMF knock him out in a car accident. When Rogosh ""wakes up"" he is in a cell in a prison in his own country, three years later, and ready to be executed as an American agent. To "prove" his loyalty to the cause, Rogosh has to spill the information on his secret operation, but during the mock trial a slip-up cues him in on the ruse. Briggs has to act fast to get Rogosh to reveal the plan to kill the citizens of Los Angeles.

The IMF team goes in as a circus team to rescue Anton Cardinal Vossek, who is being held in the impregnable Seravno Prison. Vossek is the leader of the country's freedom movement, in rebellion against Colonel Scutari, and is awaiting a fake trial before execution. With the aid of circus acrobat Crystal Walker, the team must get Vossek out. To do so, Rollin fakes being a pickpocket so as to be arrested. Once inside Servano, he has to sneak through the prison and get Vossek out of his cell as a test run for the next day...only for the guards to interrupt at an inopportune moment.

Rollin manages to avoid the guards and escape, but Vossek is moved to a new cell in solitary confinement. Briggs comes up with a new plan and manages to relay it to the imprisoned Rollin. They manage to do so, and manage to rescue Vossek from the prison. With Barney providing distraction as a clown, the team manages to get Vossek over the border before Vossek's captors can catch up to them.

Mobster Frank Egan kidnaps the daughter of Dan's friend and uses her as a hostage to force Dan and the team to break out a key witness, Augie Gorman, against him. After several failed ploys, Barney manages to contaminate Gorman's water supply inside the hotel safehouse where the police are keeping him. The team has taken over the hospital room and use a rotating examination table to switch Gorman for IMF member Steve (who resembles him). At the exchange, Egan tries to double-cross Dan, but the IMF team leader has a trick or two of his own to make sure things go smoothly and Gorman gets what's coming to him.

Enemy agent Janos Passik is preparing to train 200 foreign agents to infiltrate the U.S. and engage in some form of bacteriological warfare. The team figures out that Passik has created a replica of a ""typical American town"" so as to train his agents to learn how to blend into American society. Rollin, Cinnamon, Barney, and bacteriologist Rogr Lee replace the new group of recruits and must then find their way to the research lab. They soon realize that the American-trained agents will be infected with a highly contagious plague and then sent into American to kill millions. The group must not only destroy the plague samples but make sure that Passik and his superiors do not find out that the destruction was deliberate.

A defector has been targeted by two rival groups from the same foreign country. The team is to discredit the younger group, so that the U.S. can more easily handle the old-line group. The IMF sets it up so that the younger group's assassin, Fetyukov, must seduce Cinnamon to get to the defector. The two play a dangerous romantic game, while Dan convinces the older group's assassin, Shtemenko, that Fetyukov betrayed him to the Americans. They then get pictures of him trying to assassinate the defector, and try to blackmail him to convince him further that Fetyukov is responsible. Cinnamon ""saves"" Fetyukov and convinces him that she wants to defect. As Fetyukov goes after the defector, it's up to Cinnamon to stop him.

Miklos Klaar, an Iron Curtain filmmaker, has film of American soldiers and plans to edit it into an atrocity movie to discredit the U.S. He has recreated the jungle as a set from the one print of the film he has. Disguised as a Ministry of Propaganda officer, Rollin destroys the print and Barney floods the negative vault, forcing Klaar to reshoot the American footage as well. Cameraman and IMFer David Day is snuck in and films Klaar recreating the American footage. On the day the press is assembled, David and Willy manage to bypass Klaar's guards and air the footage of Klaar rehearsing his cast and crew and congratulating themselves on the phony massacre.

Vincent Deane is a jazz musician and undercover U.S. intelligence operative who has memorized the plans to a microcircuit code but was then captured and imprisoned. The IMF must get him out. Deane's interrogator, Brobin, has hooked Deane on drugs to try and break him using the withdrawl symptoms, unaware that the chip is concealed among some sugar cubes Deane had. Pretending to be Deane's wife, Cinnamon implicates Rollin as the real enemy agent. Brobin has Rollin captured and imprisoned,but Rollin manages to escape and tamper with Deane's drugs so that he goes into a coma. Briggs pretends to be a U.S. representative demanding Deane's body, so Brobin has it cremated to prevent a revealing autopsy. Barney and Willy switch out the ""dead"" Deane. Rollin then agrees to tell Brobin where the microcircuit is, knocks out the interrogator, and with the aid of two masks makes his escape.

In the country of Elkabar, King Ibn Borca is conducting a brisk slave business with the aid of supplier Karl de Groot. de Groot raids into neighboring countries. The IMF team must put the two men out of business. Barney lets himself be captured by de Groot, gets the info on a cell, then escapes with the info so they can create an exact duplicate of the cell. Jim "sells" Cinnamon to de Groot, then Willy retrieves her and captures de Groot. Jim then approaches de Groot's partner Jara and tells him he killed de Groot and that Jara has a new partner...

Rollin-as-Wayne orders the death of Jim, who is impersonating a federal investigator, without getting the approval of the Syndicate Council. With Jim's killing a a distraction, Rollin breaks into the safe at Syndicate HQ and duplicates the financial records. The Council, unhappy with ""Wayne's"" independence and the fact that the murder is attracting headlines, condemn him to death. Rollin runs, but at the last moment switches place with the real Wayne, who has received plastic surgeon to make him look like Rollin. Wayne is killed by the hitman, Johnny, and the records are used to bust the Syndicate.