Syndicate man Dutch Krebbs controls a large gambling operation and an undercover IMF agent with a camera-watch disappeared, presumably with recorded evidence against Krebbs. The IMF must find the agent's body and the watch. Jim poses as a pool player (being helped by Barney) to attract Krebbs' attention - Krebbs plans to use Jim to rip off a rival racketeer's best shooter, but Jim's girlfriend Mimi (formerly Press' girlfriend, now working with the IMF for revenge) reveals he's cheating to Krebbs, who believes Jim can't lose. Meanwhile the IMF rob Press, Krebbs' lieutenant, twice and Press has to make up the loss - Barney promises he can get the money by betting against Jim but Jim wins - Krebbs is accused of cheating and believes Press sold him out and orders a hit. Willy, working in the mob, tells Press about the watch and Press goes after it to get the evidence to bring down Krebbs and the team recovers the watch and takes them into custody, and Mimi signs on with the IMF.

The Syndicate plans to finance the head of the army's takeover of his country in return for the right to operate the country's vices. The IMF team must intercept the safe deposit key before it reaches the general. Willy replaces a crewman aboard the yacht, but can't find the key and is discovered. He is forced overboard, almost drowns, but escapes and helps warn the team. Jim, Barney and Mimi craft an elaborate plot to convince the bad guys' courier to reveal the location of the key.

A government scientist, Paul Morse, plans to sell a biological weapon, TOD-5, to terrorist Alpha Group led by Dr. Flory. The IMF must get to Morse's contact, Gordon Holt, and get him to take them to Alpha HQ. When Holt gets to the small town where he is to get the weapon from Morse, he finds the town under quarantine and people dying - then he starts showing (IMF-faked) symptoms of the disease. He grabs Mimi, who is supposedly immune, and takes her with him to Alpha HQ and infects them to force them to come up with an antidote - the IMF trail him and arrest the whole operation.

Carl Reid, a Syndicate cocaine distributor, has as his chief supplier Fernando Laroca, and the two of them have created an undetectable series of pickup and payoff locations. They're planning a huge shipment in 72 hours and the IMF must stop them. The IMF set up Reid's lieutenant Conrad to take them to the cocaine, although even he doesn't know where it is. The IMF set up a fake new cocaine organization with Willy as a chemist with a machine that can manufacture cocaine. Conrad makes a deal with them to undercut his boss and sell the cocaine to three big buyers - the IMF steal the money and leave him with fake cocaine, so Conrad kills one of Reid's man to find the real shipment of cocaine - when he finds it the IMF move in and the police arrest everyone.

Norman Shields is a Syndicate man controlling the entertainment industry with money supplied by Theodore Dane, and is sending his brother Benjamin with the money to finance a takeover - the IMF must get the records and bring Shields down. Jim takes Theo's place (he and Shields have never met) and backs a production of a movie based on a murder which Shields committed years ago. Willy replaces Shields' gun with blanks and during a late night confrontation he ""shoots"" Jim - the IMF get the whole thing on tape and redub it with Theo's voice. Benjamin insists on seeing the money-making film that Shields is so worried about - instead, Shields ends up showing him the IMF film where brother Theo is ""killed."" Dane takes the syndicate records from Shields, who in turns has them taken by Willy and Jim.

The IMF needs to get proof that Syndicate chief Sam Dexter murdered his girlfriend Vicki - Dexter is currently in prison on tax evasion and his unknown partner, The General, continues to extort millions. Jim the prosecutor produces Mimi the eyewitness who can place Dexter at the crime scene - when Dexter sends his hood Murdock, the IMF replace him by guest-agent Jack and after a faked accident implicates The General. Dexter's paid-off D.A., Reynolds, incriminates himself and ends up arrested but Dexter still refuses to cooperate. In the prison Dexter forces fellow con Barney to help him escape so he can confront the General and then return. When Dexter plans to kill Barney and the General, the IMF step in just in time.

The IMF has 16 hours to find a nuclear bomb placed by an extortionist, Dr. Cooper, in one of seven Pacific Coast cities and find Cooper's associates in charge of disarming the bomb. The IMF track Cooper to a cafe and fake a radio broadcast announcing his demands will be met - then Jim and Mimi break in as convicts and take Cooper and the others hostage. The IMF eventually ""let"" Cooper call his associate Rogers to disarm the bomb but Cooper's wife Adele kills Rogers when she fears the plan has gone awry. When Rogers' death is announced on the radio, a frustrated Cooper convinces Jim and Mimi to take him to the bomb (beneath City Hall) which he shuts off with seconds to spare - the IMF take him into custody.