In a world where minds can be analysed for potential threats of crime and mental instability, Inspector Tsunemori Akane is sent to deal with her first case, along with fellow inspector Ginoza and a group of Enforcers, latent criminals hired by the police to work for them. Akane’s case deals with an insane man who has taken a woman hostage and raped her, holing himself up in a building inhabited by groups of the homeless.

While Kogami is recuperating from Akane’s Paralyzer shot, she begins to worry about whether she is suited to be an Inspector after the fallout from her first case. On her second day on the job, she begins to learn more about the Enforcers she works with.

Ginoza and Akane, along with the Enforcers, are brought in to investigate a death caused by a Drone at a Drone manufacturing plant. When the Psycho-Pass of the entire staff checks out, they question whether it was an accident or possibly murder.

When the CID is brought in to investigate a disappearance of Kimihiko Hayama, they discover that not only has he been killed, but someone has taken over his net avatar, Talisman. The CID tries to track down the fake Talisman in order to find the killer.

The CID’s hunt for Kimihiko Hayama’s killer leads them to another murder with the same modus operandi. Now it’s up to the CID to figure out how to track down the killer’s real identity and get justice for the victims.

A series of bombings takes place in Tokyo. After some analysis, the detectives figure out who the culprit is and his whereabouts, and head to his location. Akane wants to be cautious, but the other Inspectors decide to rush in, and...

An Enforcer from Division 2 was executed by a Dominator and an Inspector from the same division has gone missing. The only clue they have is the mysterious message “WC?” left at the crime scene. But who could commit a crime without being detected?

The MSPWB has identified a possible hiding place for Kamui, and Divisions 1 and 3 are sent to the scene in order to investigate. Meanwhile, Akane has Saiga help with Representative Masuda’s interrogation.

After figuring out who Sakuya Togane really is, Inspector Shimotsuki also learns the truth about the Sibyl System. In the meantime, Kamui and his accomplices are moving forward with their plan using the Dominators he took from the MWPSB.