While working to track down a bombing suspect, Voight and Antonio meet with Chief Boden, who unwillingly agrees to let Dawson and Brett go undercover. As the investigation continues, Boden, Casey and Severide lend their skilled expertise in the investigation. Elsewhere, Kidd and Zach's relationship hits a bump and Cruz has a hard time expressing his true feelings for Brett. Meanwhile, Herrmann and Connie are forced to come up with an alternative solution when two birthday parties are booked on the same day at the firehouse.

The crossover starts on Chicago Fire S05E016 Profiles (I).

A spate of robberies comes to light after a firehouse lockbox key goes missing; Sergeant Hank Voight suspects a firefighter may be involved, and with Boden's support, he recruits Cruz to go undercover to help sniff out any suspicious activity.

The crossover continues on Chicago P.D. S06E15 Good Men (II).

Tensions run high between Casey and Herrmann after the firehouse responds to an apartment complex fire. After discovering something extremely suspicious during the call, Kidd and Severide do some investigating and get CPD on the case.

A rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago’s finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening.

The crossover continues on Chicago Med S05E04 Infection, Part II (II) and Chicago P.D. S07S04 Infection, Part III (III).

Mouch and Ritter work together to solve a murder mystery. Severide and Cruz tackle a food truck fire. Gallo goes to see Hawkins about Violet.

Kidd and Severide's honeymoon is interrupted by a dangerous person from their past. Kidd's former academy classmate joins Firehouse 51. Brett and Violet reflect on their relationships.

Mouch builds a classic firetruck model for the Deputy District Chief but needs some assistance from Gallo and Ritter. Brett and Violet encounter multiple victims with a strange set of symptoms. Cindy's chemotherapy results loom over the Herrmann family.