After learning the school fire wasn't an accident, Chief Boden turns up the pressure on Severide and Casey to investigate the cause of the fire that trapped his wife. Fueled by a competitive bet against Firehouse 87, Mouch pushes all of the wrong buttons in his need to win the competitive challenge known as the firefighter muster. Meanwhile, as Kidd settles into her new living arrangement, her unresolved feelings prompt her to question the intentions of newcomer Hope.

Foster faces blowback after pointing out a doctor's oversight. Brett helps Casey look for a new apartment. Kidd prepares Tuesday the Dalmatian for the Fire Safety Dog Competition. A serious accusation is leveled against Severide.

A rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago’s finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening.

The crossover continues on Chicago Med S05E04 Infection, Part II (II) and Chicago P.D. S07S04 Infection, Part III (III).

Cruz and Severide suspect foul play when a fire started by an elderly woman turns deadly. Kidd, Foster and Brett create a women’s-only lounge. Firehouse 51 celebrates some good news.

Severide must make a tough decision about the future of his career at Firehouse 51. Herrmann deals with the consequences of his temper. Cruz is excited to demonstrate the Slamigan at the Firefighting Expo. Commissioner Grissom returns.

Severide begins his assignment at the Office of Fire Investigation and gets off on the wrong foot when, despite his orders, he reopens an old case. When the cause of an apartment fire hits close to home, Herrmann is on a mission to get to the bottom of it. Kidd finds herself burning the candle at both ends.

An unexpected visit throws Casey for a loop. Severide sets out to exonerate a wrongly convicted arsonist. Kidd pays the price for burning the candle at both ends. Cruz goes on a mission to fix one of Otis’s old toys.

Members of Firehouse 51 are dismayed to learn their boundaries have been redrawn to overlap with an adjacent station and problems quickly arise. Casey and Gallo hunt a missing piece of equipment. Brett and Foster find themselves at odds. Mouch tries the find the recipient of a mysterious letter he discovers.

A mishap on the aerial ladder in the midst of a fire rescue leaves Mouch shaken and questioning his abilities. Kidd looks for support from Severide while Casey and Brett discuss their future.

A fire at a homeless encampment leaves Severide and Casey searching for answers. Cruz is shaken up after a close call. Ritter lends a helping hand to a victim.

Casey makes a life-altering decision. Gallo, Ritter and Violet agree to an interview and photo shoot. Brett and Mouch launch the paramedicine program. Cruz comes closer to fatherhood.

A major security breach in the city’s computer networks forces Firehouse 51’s senior leaders to take matters into their own hands. Severide gears up for an arson investigation.

Gallo clashes with the new lieutenant temporarily filling in for Casey. Severide closes in on a dangerous and deadly arsonist.

On a call with Station 37, a firefighter is struck by a power line and decides to lash out after her injury. Brett is visited by Scott and Amelia. Violet gets a surprise envelope. The rest of 51 enters a contest.

Severide and Seager team up to investigate a fire at the home of a troubled young woman. Pelham moves into 51's rumored cursed office. Kylie assists Kidd with Girls on Fire.

Following an injury in the aftermath of an industrial fire, Severide and Seager work together to investigate an anonymous tip. Kidd searches for the right person to fill the opening on Truck 81.

Kidd recruits Carver, Capp and Tony to help prepare her new lieutenant's quarters. Severide and Det. Pryma pair up to work a police investigation. Firehouse 51 fights a movie theater fire.

Severide and Kidd investigate an explosion at a jewelry store. Cruz and Chloe take steps to make Javi a permanent part of their family. Gallo, Ritter and Mouch try to bond with Carver.

Firehouse 51 prepares for their semi-annual firehouse inspection. Brett fights to save her paramedicine program. Commander Martin Pearce asks Severide for a favor.

Kidd, Seager and Carver investigate a fire at the city stables. Kylie clashes with some of the firefighters over changes due to budget cuts. Herrmann struggles to keep it together as Cindy's condition worsens.