After getting drunk and disorderly at her ex-boyfriend's wedding, Dr. Mindy Lahiri realizes she needs to get her personal and professional life back on track.

Mindy decides to cook Thanksgiving dinner at Gwen's house, but she is completely caught off guard when her former blind date, Dennis, arrives with his new girlfriend. Meanwhile, a lonely Danny mans the empty office while Betsy and Jeremy visit Betsy's eccentric family for the holiday.