Mindy is confronted with an awkward situation when her teenage neighbor comes to her for birth control. Meanwhile, Danny receives an anonymous complaint that Morgan has been inappropriately ogling Shauna.

When Mindy is asked to host a medical segment on the local news, she turns to Maria Menounos for help; Beverly has a difficult time keeping up with modern culture and technology when she returns to work as an administrative assistant.

Mindy's friends and co-workers unintentionally throw her the worst birthday party ever. And, after storming out, Mindy stumbles upon a new group of friends with whom to celebrate. But when she ends up in a fight with her new pals, she receives help from someone in her recent past. Meanwhile, Danny and Jeremy compete for the affection of Mindy's friend.

When Mindy decides to have a night out by herself in the city, she hits it off with a stunningly handsome man who turns out to be a prostitute.

As the doctors of Schulman and Associates prepare for a medical conference in Santa Fe, NM, Mindy receives a message from her ex-boyfriend, Josh, who is now living there and wants to talk. But Mindy is in for a surprise when she discovers why Josh moved west. Meanwhile, Morgan helps Jeremy work on a potentially career-changing presentation, which doesn’t go according to plan.

When Danny's ex-wife, Christina, comes back to New York to confront Danny about an emotional letter he had written to her, Morgan confesses that he had sent the letter unbeknownst to Danny, causing Danny to fire Morgan out of anger. Meanwhile, the rest of the staff compete in a triathlon and go head-to-head with the midwives, who have hired Morgan to work for them.

Mindy makes the bold decision to move to Haiti with Casey for a year, much to the amusement of her co-workers. In order to prove that she can survive in rough conditions, Mindy invites herself and Casey on a camping trip with Danny and his ex-wife, Christina, with whom he has recently reconciled.