As the doctors of Schulman and Associates prepare for a medical conference in Santa Fe, NM, Mindy receives a message from her ex-boyfriend, Josh, who is now living there and wants to talk. But Mindy is in for a surprise when she discovers why Josh moved west. Meanwhile, Morgan helps Jeremy work on a potentially career-changing presentation, which doesn’t go according to plan.

When Danny's ex-wife, Christina, comes back to New York to confront Danny about an emotional letter he had written to her, Morgan confesses that he had sent the letter unbeknownst to Danny, causing Danny to fire Morgan out of anger. Meanwhile, the rest of the staff compete in a triathlon and go head-to-head with the midwives, who have hired Morgan to work for them.

Mindy makes the bold decision to move to Haiti with Casey for a year, much to the amusement of her co-workers. In order to prove that she can survive in rough conditions, Mindy invites herself and Casey on a camping trip with Danny and his ex-wife, Christina, with whom he has recently reconciled.

Mindy and Casey's blissful time in Haiti is cut short when Mindy gets sick and is airlifted back to New York; Dr. Paul Leotard (James Franco), Schulman & Associates' new resident OB/GYN, shares sex therapy advice with Christina and Danny.

As Mindy adjusts to her long-distance relationship with Casey, she also must adjust to the fact that she is no longer the office's "Dr. L" - her office, patients and dignity have been overtaken by Dr. Paul Leotard - so she challenges Paul to get her former life back. Meanwhile, Danny has a new extracurricular activity following his breakup with Christina.

Mindy hits it off with a journalist named Jason, but Jason is a bit snobbish and finds Mindy to be too mainstream. To show that she's more cultured than he thinks, Mindy invites Jason to Christina's art show, where nude photos of Danny are on display.